Hereditary breast and ovarian cancer syndrome (HBOC) is clinically defined by family
history criteria, and molecularly defined by identification of germline pathogenic variants …

Hereditary cancer syndromes are inherited pathogenic genetic variants that significantly
increase the risk of develo** cancer. When individuals become aware of their increased …

Female BRCA1/2 pathogenic variant carriers have an increased lifetime risk for breast and
ovarian cancer. Cancer-unaffected women who are newly diagnosed with this pathogenic …

Introduction: A considerable number of families with pedigrees suggestive of a Mendelian
form of Breast Cancer (BC), Ovarian Cancer (OC), or Pancreatic Cancer (PC) do not show …

Simple Summary During the last few decades, the basis for a genetic predisposition for
several cancer syndromes has been clarified, and the highly penetrant/high-risk genes …

Completion of genetic testing is increasingly important for the complex care of patients with
suspected hereditary breast and ovarian cancers (HBOC) and their at-risk family members …

Breast cancer remains the most common female cancer, affecting approximately 1 in 8
women over the course of their lifetime. 1 Of the more than 300,000 cases of breast cancers …

Little is known about how women with a BRCA1/2 mutation develop an individual
understanding of their breast and ovarian cancer risk and how this affects their …

Objective Women carrying a BRCA1/2 pathogenic variant have an increased risk for breast
cancer and may opt for risk‐reducing bilateral mastectomy. In this study, we examine which …

Although BRCA1/2 genetic testing in developed countries is part of the reality for high-risk
patients for hereditary breast and ovarian cancer (HBOC), the same is not true for upper …