CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR-
associated) proteins are powerful gene-editing tools because of their ability to accurately …

Extracellular vesicles (EVs), as natural carriers of bioactive cargo, have a unique
micro/nanostructure, bioactive composition, and characteristic morphology, as well as …

Programmable approaches to sense and respond to the presence of specific RNAs in
biological systems have broad applications in research, diagnostics, and therapeutics. Here …

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a
global health emergency, and its gene mutation and evolution further posed uncertainty of …

In this work, a label-free and highly sensitive fluorescence assay was constructed for
microRNA detection. Nicking-enhanced rolling circle amplification (RCA) induced by G …

The severity of foodborne diseases caused by foods contaminated by pathogens or their
toxins creates an urgent need for the development of specific and sensitive method for …

CRISPR/Cas system is now playing an important role in biosensing applications, especially
when the trans cleavage activity of several Cas effectors is discovered. Recently …

Taking advantage of outstanding precision in target recognition and trans-cleavage ability,
the recently discovered CRISPR/Cas12a system provides an alternative opportunity for …

Foodborne pathogen infection is a key issue of food safety. Herein, we developed a label-
free assay for Salmonella enterica (S. enterica) detection based on the G-quadruplex …

Nucleic acids, with the advantages of programmability and biocompatibility, have been
widely used to design different kinds of novel biocomputing devices. Recently, nucleic acid …