The M-CSF receptor in osteoclasts and beyond

SH Mun, PSU Park, KH Park-Min - Experimental & molecular medicine, 2020 - nature.com
Colony-stimulating factor 1 receptor (CSF1R, also known as c-FMS) is a receptor tyrosine
kinase. Macrophage colony-stimulating factor (M-CSF) and IL-34 are ligands of CSF1R …

T-cell mediated inflammation in postmenopausal osteoporosis

D Wu, A Cline-Smith, E Shashkova, A Perla… - Frontiers in …, 2021 - frontiersin.org
Osteoporosis is the most prevalent metabolic bone disease that affects half the women in the
sixth and seventh decade of life. Osteoporosis is characterized by uncoupled bone …

[HTML][HTML] Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

MM McDonald, WH Khoo, PY Ng, Y **ao, J Zamerli… - Cell, 2021 - cell.com
Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/
macrophage-derived precursors that are thought to undergo apoptosis once resorption is …

[HTML][HTML] Mechanistic investigations of the mitochondrial complex I inhibitor rotenone in the context of pharmacological and safety evaluation

S Heinz, A Freyberger, B Lawrenz, L Schladt… - Scientific reports, 2017 - nature.com
Inhibitors of the mitochondrial respiratory chain complex I are suggested to exert anti-tumor
activity on those tumors relying on oxidative metabolism and are therefore of interest to …

TGFβ reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis

Y **a, K Inoue, Y Du, SJ Baker, EP Reddy… - Nature …, 2022 - nature.com
It is well-established that receptor activator of NF-κB ligand (RANKL) is the inducer of
physiological osteoclast differentiation. However, the specific drivers and mechanisms …

Autophagy proteins regulate the secretory component of osteoclastic bone resorption

CJ DeSelm, BC Miller, W Zou, WL Beatty, E van Meel… - Developmental cell, 2011 - cell.com
Osteoclasts resorb bone via the ruffled border, whose complex folds are generated by
secretory lysosome fusion with bone-apposed plasma membrane. Lysosomal fusion with the …

Effects of obesity on bone metabolism

JJ Cao - Journal of orthopaedic surgery and research, 2011 - Springer
Obesity is traditionally viewed to be beneficial to bone health because of well-established
positive effect of mechanical loading conferred by body weight on bone formation, despite …

The origins and roles of osteoclasts in bone development, homeostasis and repair

Y Yahara, T Nguyen, K Ishikawa, K Kamei… - …, 2022 - journals.biologists.com
The mechanisms underlying bone development, repair and regeneration are reliant on the
interplay and communication between osteoclasts and other surrounding cells. Osteoclasts …

Retracted article: miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2

JY Krzeszinski, W Wei, HD Huynh, Z **, X Wang… - Nature, 2014 - nature.com
Bone-resorbing osteoclasts significantly contribute to osteoporosis and bone metastases of
cancer,,. MicroRNAs play important roles in physiology and disease,, and present …

Defective autophagy in osteoblasts induces endoplasmic reticulum stress and causes remarkable bone loss

H Li, D Li, Z Ma, Z Qian, X Kang, X **, F Li, X Wang… - Autophagy, 2018 - Taylor & Francis
Macroautophagy/autophagy is a highly regulated process involved in the turnover of
cytosolic components, however its pivotal role in maintenance of bone homeostasis remains …