The M-CSF receptor in osteoclasts and beyond
Colony-stimulating factor 1 receptor (CSF1R, also known as c-FMS) is a receptor tyrosine
kinase. Macrophage colony-stimulating factor (M-CSF) and IL-34 are ligands of CSF1R …
kinase. Macrophage colony-stimulating factor (M-CSF) and IL-34 are ligands of CSF1R …
T-cell mediated inflammation in postmenopausal osteoporosis
D Wu, A Cline-Smith, E Shashkova, A Perla… - Frontiers in …, 2021 - frontiersin.org
Osteoporosis is the most prevalent metabolic bone disease that affects half the women in the
sixth and seventh decade of life. Osteoporosis is characterized by uncoupled bone …
sixth and seventh decade of life. Osteoporosis is characterized by uncoupled bone …
[HTML][HTML] Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption
Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/
macrophage-derived precursors that are thought to undergo apoptosis once resorption is …
macrophage-derived precursors that are thought to undergo apoptosis once resorption is …
[HTML][HTML] Mechanistic investigations of the mitochondrial complex I inhibitor rotenone in the context of pharmacological and safety evaluation
S Heinz, A Freyberger, B Lawrenz, L Schladt… - Scientific reports, 2017 - nature.com
Inhibitors of the mitochondrial respiratory chain complex I are suggested to exert anti-tumor
activity on those tumors relying on oxidative metabolism and are therefore of interest to …
activity on those tumors relying on oxidative metabolism and are therefore of interest to …
TGFβ reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis
It is well-established that receptor activator of NF-κB ligand (RANKL) is the inducer of
physiological osteoclast differentiation. However, the specific drivers and mechanisms …
physiological osteoclast differentiation. However, the specific drivers and mechanisms …
Autophagy proteins regulate the secretory component of osteoclastic bone resorption
Osteoclasts resorb bone via the ruffled border, whose complex folds are generated by
secretory lysosome fusion with bone-apposed plasma membrane. Lysosomal fusion with the …
secretory lysosome fusion with bone-apposed plasma membrane. Lysosomal fusion with the …
Effects of obesity on bone metabolism
JJ Cao - Journal of orthopaedic surgery and research, 2011 - Springer
Obesity is traditionally viewed to be beneficial to bone health because of well-established
positive effect of mechanical loading conferred by body weight on bone formation, despite …
positive effect of mechanical loading conferred by body weight on bone formation, despite …
The origins and roles of osteoclasts in bone development, homeostasis and repair
Y Yahara, T Nguyen, K Ishikawa, K Kamei… - …, 2022 - journals.biologists.com
The mechanisms underlying bone development, repair and regeneration are reliant on the
interplay and communication between osteoclasts and other surrounding cells. Osteoclasts …
interplay and communication between osteoclasts and other surrounding cells. Osteoclasts …
Retracted article: miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2
Bone-resorbing osteoclasts significantly contribute to osteoporosis and bone metastases of
cancer,,. MicroRNAs play important roles in physiology and disease,, and present …
cancer,,. MicroRNAs play important roles in physiology and disease,, and present …
Defective autophagy in osteoblasts induces endoplasmic reticulum stress and causes remarkable bone loss
Macroautophagy/autophagy is a highly regulated process involved in the turnover of
cytosolic components, however its pivotal role in maintenance of bone homeostasis remains …
cytosolic components, however its pivotal role in maintenance of bone homeostasis remains …