Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility
The hypothalamic–pituitary–adrenal (HPA) axis is the major neuroendocrine axis regulating
homeostasis in mammals. Glucocorticoid hormones are rapidly synthesized and secreted …
homeostasis in mammals. Glucocorticoid hormones are rapidly synthesized and secreted …
Cortisol and major depressive disorder—translating findings from humans to animal models and back
Major depressive disorder (MDD) is a global problem for which current pharmacotherapies
are not completely effective. Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has …
are not completely effective. Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has …
Gene–stress–epigenetic regulation of FKBP5: clinical and translational implications
Stress responses and related outcomes vary markedly across individuals. Elucidating the
molecular underpinnings of this variability is of great relevance for develo** individualized …
molecular underpinnings of this variability is of great relevance for develo** individualized …
Understanding the molecular mechanisms underpinning gene by environment interactions in psychiatric disorders: the FKBP5 model
Epidemiologic and genetic studies suggest common environmental and genetic risk factors
for a number of psychiatric disorders, including depression, bipolar disorder, and …
for a number of psychiatric disorders, including depression, bipolar disorder, and …
Gene–environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism
Psychiatric phenotypes are multifactorial and polygenic, resulting from the complex interplay
of genes and environmental factors that act cumulatively throughout an organism's lifetime …
of genes and environmental factors that act cumulatively throughout an organism's lifetime …
Selective inhibitors of the FK506-binding protein 51 by induced fit
S Gaali, A Kirschner, S Cuboni, J Hartmann… - Nature chemical …, 2015 - nature.com
Abstract The FK506-binding protein 51 (FKBP51, encoded by the FKBP5 gene) is an
established risk factor for stress-related psychiatric disorders such as major depression …
established risk factor for stress-related psychiatric disorders such as major depression …
Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5
Responding to different dynamic levels of stress is critical for mammalian survival. Disruption
of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) signaling is proposed to …
of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) signaling is proposed to …
FKBP ligands—where we are and where to go?
JM Kolos, AM Voll, M Bauder, F Hausch - Frontiers in pharmacology, 2018 - frontiersin.org
In recent years, many members of the FK506-binding protein (FKBP) family were
increasingly linked to various diseases. The binding domain of FKBPs differs only in a few …
increasingly linked to various diseases. The binding domain of FKBPs differs only in a few …
Hsp90: structure and function
SE Jackson - Molecular chaperones, 2013 - Springer
Hsp90 is a highly abundant and ubiquitous molecular chaperone which plays an essential
role in many cellular processes including cell cycle control, cell survival, hormone and other …
role in many cellular processes including cell cycle control, cell survival, hormone and other …
The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice
Disturbed activation or regulation of the stress response through the hypothalamic-pituitary-
adrenal (HPA) axis is a fundamental component of multiple stress-related diseases …
adrenal (HPA) axis is a fundamental component of multiple stress-related diseases …