Endogenous cytoplasmic DNA (cytoDNA) species are emerging as key mediators of
inflammation in diverse physiological and pathological contexts. Although the role of …

Maintenance of genome stability requires control over the expression of transposable
elements (TEs), whose activity can have substantial deleterious effects on the host …

N 6-methyladenosine (m6A) is the most abundant internal modification on mammalian
messenger RNA. It is installed by a writer complex and can be reversed by erasers such as …

Transposable elements represent nearly half of mammalian genomes and are generally
described as parasites, or" junk DNA." The LINE1 retrotransposon is the most abundant …

Mammalian fertilization begins with the fusion of two specialized gametes, followed by major
epigenetic remodeling leading to the formation of a totipotent embryo. During the …

Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …

Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections, and comprise
nearly 8% of the human genome. The most recently acquired human ERV is HERVK (HML …

Effective antiviral protection in multicellular organisms relies on both cell-autonomous and
systemic immunity. Systemic immunity mediates the spread of antiviral signals from infection …

After fertilization, to initiate development, gametes are reprogramed to become totipotent.
Approximately half of the mammalian genome consists of repetitive elements, including …

Transposable elements (TEs) or “jum** genes” historically have been disparaged as a
class of “junk DNA” in mammalian genomes (1, 2). The advent of whole genome DNA …