G protein-coupled, seven-transmembrane segment receptors (GPCRs or 7TM receptors),
with more than 1000 different members, comprise the largest superfamily of proteins in the …

The superfamily of G-protein-coupled receptors (GPCRs) could be subclassified into 7
families (A, B, large N-terminal family B-7 transmembrane helix, C, Frizzled/Smoothened …

A fundamental goal in cellular signaling is to understand allosteric communication, the
process by which signals originating at one site in a protein propagate reliably to affect …

Nearly 2000 G protein-coupled receptors (GPCRs) 1 have been reported since bovine opsin
was cloned in 1983 (1) and the-adrenergic receptor in 1986 (2). They are classified into over …

Molecular cloning studies have shown that G-protein-coupled receptors form one of the
largest protein families found in nature, and it is estimated that approximately 1000 different …

The adrenergic receptors play a key role in the modulation of sympathetic nervous system
activity as well as a site of action for many therapeutic agents. The α 1-adrenergic receptor …

Here, we represent protein structures as residue interacting networks, which are assumed to
involve a permanent flow of information between amino acids. By removal of nodes from the …

Concepts regarding the mechanisms by which drugs activate receptors to produce
physiological response have progressed beyond considering the re¬ ceptor as a simple on …

Efficacy has been defined in receptor pharmacology as a proportionality factor denoting the
amount of physiological response a given ligand imparts to a biological system for a given …

Dimerization is fairly common in the G-protein-coupled receptor (GPCR) superfamily. First
attempts to rationalize this phenomenon gave rise to an idea that two receptors in a dimer …