When cancer metastasizes to bone, considerable pain and deregulated bone remodelling
occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and …

Bone and the immune system are both complex tissues that respectively regulate the
skeleton and the body's response to invading pathogens. It has now become clear that these …

Metastatic disease is the culmination of cancer and its most common life-threatening
manifestation. The highly complex process by which cancer cells disseminate to and …

Multiple myeloma (MM) is a neoplasm of post–germinal center, terminally differentiated B
cells. It is characterized by a multifocal proliferation of clonal, long-lived plasma cells within …

Cell–cell fusion in sexually reproducing organisms is a mechanism to merge gamete
genomes and, in multicellular organisms, it is a strategy to sculpt organs, such as muscle …

Sažetak Bone and immune system are functionally interconnected. Immune and bone cells
derive from same progenitors in the bone marrow, they share a common microenvironment …

The causes of metastasis remain elusive despite vast information on cancer cells. We posit
that cancer cell fusion with macrophages or other migratory bone marrow-derived cells …

Osteoclast (OC)–mediated lytic bone disease remains a cause of major morbidity in multiple
myeloma. Here we demonstrate the critical role of interleukin-17–producing marrow …

Cell fusion plays an essential role in fertilization, formation of placenta, bone and muscle
tissues, immune response, tissue repair, and regeneration. Increasing recognition of cell …

The ability to fuse cells is shared by many viruses, including common human pathogens and
several endogenous viruses. Here we will discuss how cell fusion can link viruses to cancer …