TGFβ-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer
Metastasis is the most frequent cause of death in cancer patients. Epithelial-to-mesenchymal
transition (EMT) is the process in which cells lose epithelial integrity and become motile, a …
transition (EMT) is the process in which cells lose epithelial integrity and become motile, a …
The interplay between TGF-β signaling and cell metabolism
H Liu, YG Chen - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
The transforming growth factor-β (TGF-β) signaling plays a critical role in the development
and tissue homeostasis in metazoans, and deregulation of TGF-β signaling leads to many …
and tissue homeostasis in metazoans, and deregulation of TGF-β signaling leads to many …
Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq
Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive
intratumoral heterogeneity. To investigate the underlying biology, we conducted single-cell …
intratumoral heterogeneity. To investigate the underlying biology, we conducted single-cell …
Immature natural killer cells promote progression of triple-negative breast cancer
Natural killer (NK) cells are cytotoxic lymphocytes that accumulate within the tumor
microenvironment and are generally considered to be antitumorigenic. Using single-cell …
microenvironment and are generally considered to be antitumorigenic. Using single-cell …
Membrane lipidome of an epithelial cell line
Tissue differentiation is an important process that involves major cellular membrane
remodeling. We used Madin–Darby canine kidney cells as a model for epithelium formation …
remodeling. We used Madin–Darby canine kidney cells as a model for epithelium formation …
Inhibition of glycosphingolipid synthesis with eliglustat in combination with immune checkpoint inhibitors in advanced cancers: Preclinical evidence and phase I …
L Dong, Z Cao, M Chen, Y Liu, X Ma, Y Lu… - Nature …, 2024 - nature.com
Glycosphingolipids (GSLs) are abundantly expressed in cancer cells. The effects of GSL-
targeted immunotherapies are not fully understood. Here, we show that the inhibition of GSL …
targeted immunotherapies are not fully understood. Here, we show that the inhibition of GSL …
MYC as a multifaceted regulator of tumor microenvironment leading to metastasis
EM Meškytė, S Keskas, Y Ciribilli - International Journal of Molecular …, 2020 - mdpi.com
The Myc family of oncogenes is deregulated in many types of cancer, and their over-
expression is often correlated with poor prognosis. The Myc family members are …
expression is often correlated with poor prognosis. The Myc family members are …
Epithelial Mesenchymal Transition Traits in Human Breast Cancer Cell Lines Parallel the CD44hi/CD24lo/- Stem Cell Phenotype in Human Breast Cancer
We review here the recently emerging relationship between epithelial-mesenchymal
transition (EMT) and breast cancer stem cells (BCSC), and provide analyses of published …
transition (EMT) and breast cancer stem cells (BCSC), and provide analyses of published …
Targeting the metabolic reprogramming that controls epithelial-to-mesenchymal transition in aggressive tumors
The epithelial-to-mesenchymal transition (EMT) process allows the trans-differentiation of a
cell with epithelial features into a cell with mesenchymal characteristics. This process has …
cell with epithelial features into a cell with mesenchymal characteristics. This process has …
The morphological and molecular features of the epithelial-to-mesenchymal transition
Here we describe several methods for the characterization of epithelial–mesenchymal
transition (EMT) at the cellular, molecular and behavioral level. This protocol describes both …
transition (EMT) at the cellular, molecular and behavioral level. This protocol describes both …