Mitochondria are cellular organelles that orchestrate a vast range of biological processes,
from energy production and metabolism to cell death and inflammation. Despite this …

REVIEW A variety of key events in apoptosis focus on mitochondria, including the release of
caspase activators (such as cytochrome c), changes in electron transport, loss of …

Macrophages activated by the Gram-negative bacterial product lipopolysaccharide switch
their core metabolism from oxidative phosphorylation to glycolysis. Here we show that …

Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed
by proteases called caspases. The Bcl2 family of intracellular proteins is the central …

We report here that BID, a BH3 domain–containing proapoptotic Bcl2 family member, is a
specific proximal substrate of Casp8 in the Fas apoptotic signaling pathway. While full …

Mitochondria play a key part in the regulation of apoptosis (cell death),. Their intermembrane
space contains several proteins that are liberated through the outer membrane in order to …

A variety of physiological death signals, as well as pathological cellular insults, trigger the
genetically programmed pathway of apoptosis (Vaux and Korsmeyer 1999). Apoptosis …

▪ Abstract Apoptosis is a genetically programmed, morphologically distinct form of cell death
that can be triggered by a variety of physiological and pathological stimuli. Studies …

Caspases are intracellular proteases that function as initiators and effectors of apoptosis.
The kinase Akt and p21-Ras, an Akt activator, induced phosphorylation of pro–caspase-9 …

Apoptosis is a physiological cell suicide program that is critical for the development and
maintenance of healthy tissues. Dysregulation of cell death pathways occur in cancer …