ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …

Abstract Poly (ADP-ribose) polymerase 1 (PARP1) is a first responder that recognizes DNA
damage and facilitates its repair. Neurodegenerative diseases, characterized by progressive …

PARP1, an established anti-cancer target that regulates many cellular pathways, including
DNA repair signaling, has been intensely studied for decades as a poly (ADP-ribosyl) …

In the mammalian DNA damage response, ADP-ribosylation signalling is of crucial
importance to mark sites of DNA damage as well as recruit and regulate repairs factors …

Nucleosomes, the basic structural units of chromatin, hinder recruitment and activity of
various DNA repair proteins, necessitating modifications that enhance DNA accessibility …

The timely removal of ADP-ribosylation is crucial for efficient DNA repair. However, much
remains to be discovered about ADP-ribosylhydrolases. Here, we characterize the …

PARP enzymes transfer ADP-ribose from NAD+ onto proteins as a covalent modification that
regulates multiple aspects of cell biology. Here, we identify an undiscovered catalytic activity …

The formation of nuclear biomolecular condensates is often associated with local
accumulation of proteins at a site of DNA damage. The key role in the formation of DNA …

Double-strand breaks (DSBs) are the most lethal form of DNA damage. Transcriptional
activity at DSBs, as well as transcriptional repression around DSBs, are both required for …

ABSTRACT ADP-ribose is a versatile modification that plays a critical role in diverse cellular
processes. The addition of this modification is catalyzed by ADP-ribosyltransferases, among …