Fusobacterium nucleatum, a key pathogenic factor and microbial biomarker for colorectal cancer
N Wang, JY Fang - Trends in Microbiology, 2023 - cell.com
Colorectal cancer (CRC), one of the most prevalent cancers, has complex etiology. The
dysbiosis of intestinal bacteria has been highlighted as an important contributor to CRC …
dysbiosis of intestinal bacteria has been highlighted as an important contributor to CRC …
miRNAs driving diagnosis, progression, and drug resistance in multiple myeloma
Multiple myeloma (MM) is a tumor of transformed plasma cells. It's the second most common
hematologic cancer after non-Hodgkin lymphoma. MM is a complex disease with many …
hematologic cancer after non-Hodgkin lymphoma. MM is a complex disease with many …
From tumour heterogeneity to advances in precision treatment of colorectal cancer
CJA Punt, M Koopman, L Vermeulen - Nature reviews Clinical oncology, 2017 - nature.com
In recent years, the high heterogeneity of colorectal cancer (CRC) has become evident.
Hence, biomarkers need to be developed that enable the stratification of patients with CRC …
Hence, biomarkers need to be developed that enable the stratification of patients with CRC …
Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells
Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
Serine, glycine and one-carbon units: cancer metabolism in full circle
JW Locasale - Nature Reviews Cancer, 2013 - nature.com
One-carbon metabolism involving the folate and methionine cycles integrates nutritional
status from amino acids, glucose and vitamins, and generates diverse outputs, such as the …
status from amino acids, glucose and vitamins, and generates diverse outputs, such as the …
The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/β-catenin signaling
P Han, J Li, B Zhang, J Lv, Y Li, X Gu, Z Yu, Y Jia, X Bai… - Molecular cancer, 2017 - Springer
Background With more than 600,000 mortalities each year, colorectal cancer (CRC) is the
third most commonly diagnosed type of cancer worldwide. Recently, mechanisms involving …
third most commonly diagnosed type of cancer worldwide. Recently, mechanisms involving …
Stromal contribution to the colorectal cancer transcriptome
Recent studies identified a poor-prognosis stem/serrated/mesenchymal (SSM)
transcriptional subtype of colorectal cancer (CRC). We noted that genes upregulated in this …
transcriptional subtype of colorectal cancer (CRC). We noted that genes upregulated in this …
Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation
A large proportion of colorectal cancers (CRCs) display mutational inactivation of the TGF-β
pathway, yet, paradoxically, they are characterized by elevated TGF-β production. Here, we …
pathway, yet, paradoxically, they are characterized by elevated TGF-β production. Here, we …
A molecularly annotated platform of patient-derived xenografts (“xenopatients”) identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal …
Only a fraction of patients with metastatic colorectal cancer receive clinical benefit from
therapy with anti-epidermal growth factor receptor (EGFR) antibodies, which calls for the …
therapy with anti-epidermal growth factor receptor (EGFR) antibodies, which calls for the …
A survey of tools for variant analysis of next-generation genome sequencing data
S Pabinger, A Dander, M Fischer… - Briefings in …, 2014 - academic.oup.com
Recent advances in genome sequencing technologies provide unprecedented opportunities
to characterize individual genomic landscapes and identify mutations relevant for diagnosis …
to characterize individual genomic landscapes and identify mutations relevant for diagnosis …