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Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication
Treslin, a TopBP1-interacting protein, is necessary for deoxyribonucleic acid (DNA)
replication in vertebrates. Association between Treslin and TopBP1 requires cyclin …
replication in vertebrates. Association between Treslin and TopBP1 requires cyclin …
Initiation of DNA replication: functional and evolutionary aspects
JA Bryant, SJ Aves - Annals of botany, 2011 - academic.oup.com
Background The initiation of DNA replication is a very important and highly regulated step in
the cell division cycle. It is of interest to compare different groups of eukaryotic organisms (a) …
the cell division cycle. It is of interest to compare different groups of eukaryotic organisms (a) …
Cyclin-dependent kinase regulates the length of S phase through TICRR/TRESLIN phosphorylation
CG Sansam, D Goins, JC Siefert… - Genes & …, 2015 - genesdev.cshlp.org
S-phase cyclin-dependent kinases (CDKs) stimulate replication initiation and accelerate
progression through the replication timing program, but it is unknown which CDK substrates …
progression through the replication timing program, but it is unknown which CDK substrates …
Emerging players in the initiation of eukaryotic DNA replication
Z Shen, SG Prasanth - Cell division, 2012 - Springer
Faithful duplication of the genome in eukaryotes requires ordered assembly of a multi-
protein complex called the pre-replicative complex (pre-RC) prior to S phase; transition to …
protein complex called the pre-replicative complex (pre-RC) prior to S phase; transition to …
CDK phosphorylation of SLD-2 is required for replication initiation and germline development in C. elegans
The development of a multicellular organism requires the coordination of cell proliferation
with differentiation. CDK plays a critical role in cell division across eukaryotes, but little is …
with differentiation. CDK plays a critical role in cell division across eukaryotes, but little is …
DNA Replication Checkpoint Signaling Depends on a Rad53–Dbf4 N-Terminal Interaction in Saccharomyces cerevisiae
Abstract Dbf4-dependent kinase (DDK) and cyclin-dependent kinase (CDK) are essential to
initiate DNA replication at individual origins. During replication stress, the S-phase …
initiate DNA replication at individual origins. During replication stress, the S-phase …
Interaction between DUE-B and Treslin is required to load Cdc45 on chromatin in human cells
A key step in the initiation of eukaryotic DNA replication is the binding of the activator protein
Cdc45 to promote MCM helicase unwinding of the origin template. We show here that the c …
Cdc45 to promote MCM helicase unwinding of the origin template. We show here that the c …
[PDF][PDF] Investigating the involvement of FHA domain lateral surfaces in DNA damage and cell cycle checkpoint responses in Saccharomyces cerevisiae
G Straker - 2023 - uwspace.uwaterloo.ca
Since the discovery of the Forkhead-associated (FHA) domain in 1995, research groups
have pursued the characterization of FHA domains and the interactions that they regulate …
have pursued the characterization of FHA domains and the interactions that they regulate …
Aberrant DNA Replication at an Ectopic Chromosomal Site in Human Cells
X Chen - 2011 - rave.ohiolink.edu
Aberrant DNA replication, including over-replication or under-replication may lead to life-
threatening mutation or even cause human diseases. This thesis focused on three issues …
threatening mutation or even cause human diseases. This thesis focused on three issues …
Cellular Effects of Replicating a Polypurine-Polypyrimidine Sequence and the Interactions of DUE-B with Replication Proteins
SL Myers - 2010 - rave.ohiolink.edu
CELLULAR EFFECTS OF REPLICATING A POLYPURINE-POLYPYRIMIDINE SEQUENCE
AND THE INTERACTIONS OF DUE-B WITH REPLICATION PROTEINS Page 1 CELLULAR …
AND THE INTERACTIONS OF DUE-B WITH REPLICATION PROTEINS Page 1 CELLULAR …