It has been 60 yr since the discovery of reactive oxygen species (ROS) in biology and the
beginning of the scientific community's attempt to understand the impact of the unpaired …

A constant supply of oxygen is indispensable for cardiac viability and function. However, the
role of oxygen and oxygen-associated processes in the heart is complex, and they and can …

cellular apoptosis signaling kinase-1, a redox-sensitive kinase upstream of Jun-nuclear
kinase and p38. Apoptosis signaling kinase-1 overexpression activates nuclear factor κB to …

Hypertension is associated with an elevation of reactive oxygen species (ROS) and
frequently also with an impairment of endogenous antioxidant mechanisms. Experimental …

Oxidative response regulates many physiological response in human health, but if not
properly regulated it could also lead to a number of deleterious effects. The importance of …

Growing evidences suggest a role of oxidative stress in hypertension and cardiac
hypertrophy. The fructose (60%)-fed rat represents a model of metabolic syndrome …

Background—Biological mechanisms underlying statin and angiotensin II type 1 receptor
blocker therapies differ. Therefore, we compared vascular and metabolic responses to these …

Background—HMG-CoA reductase inhibitors (statins) are lipid-lowering drugs that also
exert pleiotropic vasculoprotective effects via activation of the endothelial NO synthesis. NO …

A multitude of studies in experimental animals, together with clinical data, provide evidence
that increased production of ROS (reactive oxygen species) are involved in the development …

Insulin resistance and oxidative stress act synergistically in the development of
cardiovascular complications. The present study compared the efficacy of three polyphenolic …