[HTML][HTML] The role of curcumin in aging and senescence: Molecular mechanisms

A Zia, T Farkhondeh, AM Pourbagher-Shahri… - Biomedicine & …, 2021 - Elsevier
Healthy aging and human longevity are intricate phenotypes affected by environmental
factors such as physical exercise, diet, health habits, and psychosocial situations as well as …

Linking diet to acne metabolomics, inflammation, and comedogenesis: an update

BC Melnik - Clinical, cosmetic and investigational dermatology, 2015 - Taylor & Francis
Acne vulgaris, an epidemic inflammatory skin disease of adolescence, is closely related to
Western diet. Three major food classes that promote acne are: 1) hyperglycemic …

Healthy aging diets other than the Mediterranean: a focus on the Okinawan diet

DC Willcox, G Scapagnini, BJ Willcox - Mechanisms of ageing and …, 2014 - Elsevier
The traditional diet in Okinawa is anchored by root vegetables (principally sweet potatoes),
green and yellow vegetables, soybean-based foods, and medicinal plants. Marine foods …

Effect of antioxidants supplementation on aging and longevity

I Sadowska-Bartosz, G Bartosz - BioMed research international, 2014 - Wiley Online Library
If aging is due to or contributed by free radical reactions, as postulated by the free radical
theory of aging, lifespan of organisms should be extended by administration of exogenous …

[HTML][HTML] Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response

JA McCubrey, LS Steelman, WH Chappell… - Oncotarget, 2012 - ncbi.nlm.nih.gov
Abstract The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …

Reductive metabolites of curcumin and their therapeutic effects

A Pandey, M Chaturvedi, S Mishra, P Kumar… - Heliyon, 2020 - cell.com
Curcumin, a secondary metabolite from the turmeric plant is one of the most promising
natural products, which has been studied extensively for decades. It has demonstrated …

Tetrahydrocurcumin ameliorates diabetic cardiomyopathy by attenuating high glucose‐induced oxidative stress and fibrosis via activating the SIRT1 pathway

K Li, M Zhai, L Jiang, F Song, B Zhang… - Oxidative medicine …, 2019 - Wiley Online Library
Hyperglycemia‐induced oxidative stress and fibrosis play a crucial role in the development
of diabetic cardiomyopathy (DCM). Tetrahydrocurcumin (THC), a major bioactive metabolite …

Molecular mechanisms of hypolipidemic effects of curcumin

JM Zingg, ST Hasan, M Meydani - Biofactors, 2013 - Wiley Online Library
Recent evidence suggests potential benefits from phytochemicals and micronutrients in
reducing the elevated oxidative and lipid‐mediated stress associated with inflammation …

Radiosensitizing effect of curcumin-loaded lipid nanoparticles in breast cancer cells

L Minafra, N Porcino, V Bravatà, D Gaglio… - Scientific reports, 2019 - nature.com
In breast cancer (BC) care, radiotherapy is considered an efficient treatment, prescribed both
for controlling localized tumors or as a therapeutic option in case of inoperable, incompletely …

[HTML][HTML] Pharmaceutical and nutraceutical activation of FOXO3 for healthy longevity

RL McIntyre, YJ Liu, M Hu, BJ Morris, BJ Willcox… - Ageing research …, 2022 - Elsevier
Life expectancy has increased substantially over the last 150 years. Yet this means that now
most people also spend a greater length of time suffering from various age-associated …