Insulin resistance has long been associated with obesity. More than 40 years ago, Randle
and colleagues postulated that lipids impaired insulin-stimulated glucose use by muscles …

Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for
the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR …

Background: p53 is a tumor suppressor protein involved in regulating a wide array of
signaling pathways. The role of p53 in the cell is determined by the type of imposed …

Aims/hypothesis Increased intra-abdominal fat is associated with insulin resistance and an
atherogenic lipoprotein profile. Circulating concentrations of adiponectin, an adipocyte …

Although abdominal obesity or visceral obesity is considered to be one of the components of
metabolic syndrome and to have an important role in a cluster of cardiovascular risks, there …

Understanding pathophysiology and identifying mothers at risk of major pregnancy
complications is vital to effective prevention and optimal management. However, in current …

Background: Recent studies point to the adipose tissue as a highly active endocrine organ
secreting a range of hormones. Leptin, ghrelin, adiponectin, and resistin are considered to …

Abstract Adiponectin, also called GBP-28, apM1, AdipoQ and Acrp30, is a novel adipose
tIssue-specific protein that has structural homology to collagen VIII and X and complement …

Recent research has shown that adi-pose tissue is not simply an inert storage depot for
lipids but is also an important endocrine organ that plays a key role in the integration of …