Cancer, a complex and multifactorial disease, presents a significant challenge to global
health. Despite significant advances in surgical, radiotherapeutic and immunological …

During the past recent years, various therapies emerged in the era of breast cancer. Breast
cancer is a heterogeneous disease in which genetic and environmental factors are involved …

Drug repurposing (DR)(also known as drug repositioning) is a process of identifying new
therapeutic use (s) for old/existing/available drugs. It is an effective strategy in discovering or …

Drug repurposing is using an existing drug for a new treatment that was not indicated before.
It has received immense attention during the COVID-19 pandemic emergency. Drug …

De novo drug development is an expensive and time-consuming process. It is known that
the total average development cost for a new drug ranges from $2 to $3 billion and the total …

Tumor tissue is composed of cancer cells and surrounding stromal cells with diverse
genetic/epigenetic backgrounds, a situation known as intra-tumoral heterogeneity. Cancer …

Motivation: Drug repositioning, which aims to identify new indications for existing drugs,
offers a promising alternative to reduce the total time and cost of traditional drug …

Computational drug repositioning or repurposing is a promising and efficient tool for
discovering new uses from existing drugs and holds the great potential for precision …

Background Since the beginning of the novel coronavirus (SARS-CoV-2) disease outbreak,
there has been an increasing interest in finding a potential therapeutic agent for the disease …

Drug repositioning can drastically decrease the cost and duration taken by traditional drug
research and development while avoiding the occurrence of unforeseen adverse events …