p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is
dysregulated in some cancers. Earlier observations on p21 knockout models emphasized …

p21 cip1/waf1 mediates various biological activities by sensing and responding to multiple
stimuli, via p53-dependent and independent pathways. p21 is known to act as a tumor …

Background RNA-seq is widely used for transcriptomic profiling, but the bioinformatics
analysis of resultant data can be time-consuming and challenging, especially for biologists …

The long noncoding RNA (lncRNA) MIR22HG has previously been identified as a prognostic
marker in hepatocellular carcinoma. Here, we performed a comprehensive analysis of …

An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play
important roles in diverse cellular processes, including proliferation, apoptosis, migration …

Abstract Background Long noncoding RNAs (lncRNAs) have emerged as important
regulators of tumorigenesis and cancer progression. Recently, the lncRNA AGAP2-AS1 was …

Long non-coding RNAs (lncRNAs) have emerged as critical regulators of epigenome,
modulating gene expression through DNA methylation, histone modification, and/or …

Background Recent studies have shown that the classic hypoglycemic drug metformin
inhibits tumor growth; however, the underlying mechanism remains unclear. We previously …

Accumulating evidence indicates a correlation between circadian dysfunction and genomic
instability. However, whether the circadian machinery directly regulates DNA damage repair …

The role of vascular endothelial growth factor (VEGF) in cancer cells is not limited to
angiogenesis; there are also multiple factors, such as neuropilins (non-tyrosine kinases …