Conspectus The growing importance of axially chiral architectures in different scientific
domains has unveiled shortcomings in terms of efficient synthetic access and skeletal …

C–H functionalization has been emerging as a powerful method to establish carbon–carbon
and carbon–heteroatom bonds. Many efforts have been devoted to transition-metal …

Abstract Frustrated Lewis pairs (FLPs) are well documented for the activation of small
molecules such as dihydrogen and carbon dioxide,,–. Although canonical FLP chemistry is …

Conspectus α-Diazocarbonyl compounds serve as nucleophiles, dipoles, carbene
precursors, and rare electrophiles, enabling a vast array of organic transformations under …

Asymmetric sp3 C–H functionalization has been demonstrated to substantially expedite
target molecule synthesis, spanning from feedstocks upgradation to late-stage modification …

The ability to selectively introduce diverse functionality onto hydrocarbons is of substantial
value in the synthesis of both small molecules and polymers. Herein, we report an approach …

C–H functionalization has become widely recognized as an exciting new strategy for the
synthesis of complex molecular targets. Instead of relying on functional groups as the …

The construction of carbon–carbon bonds is a central tenet of modern synthetic chemistry.
Metal-catalyzed C–H functionalization can serve as a particularly powerful tool for achieving …

The direct and selective C (sp3)-H functionalization of cycloalkanes and alkanes is a highly
useful process in organic synthesis owing to the low-cost starting materials, the high step …

The magic methyl effect is well acknowledged in medicinal chemistry, but despite its
significance, accessing such analogues via derivatization at a late stage remains a pivotal …