The development and application of emerging technologies of Industry 4.0 enable the
realization of digital twins (DT), which facilitates the transformation of the manufacturing …

The bioprocessing industry is undergoing a significant transformation in its approach to
quality assurance, shifting from the traditional Quality by Testing (QbT) to Quality by Design …

Research emphases on extensive experimental studies and modeling efforts have been on
the rise for the development of accurate predictive models of pharmaceutical unit operations …

The pharmaceutical industry is going through a significant change to adopt smart
manufacturing for more integrated supply chains and improved sustainability. Today's …

Quality is the lifeline for all pharmaceuticals. Process analytical technology (PAT),
introduced by FDA in 2004, providing significant opportunities for improving pharmaceutical …

This paper presents surrogate models of dissolution behavior to identify the critical input
parameters in tablet manufacturing processes. Dissolution behavior is a critical quality …

This paper presents a generic framework of Model Driven Design (MDD) with its application
for a twin screw granulation process using a mechanistic-based population balance model …

The capabilities of digital twins (DT) and the successes they have demonstrated in various
industries have attracted significant attention from the biopharmaceutical manufacturing …

Traditional operation modes, such as running the production processes at constant process
settings or within a narrow design space, do not fully exploit the advantages of continuous …

The global pharmaceutical industry is a trillion‐dollar market. However, the pharmaceutical
sector often lags in manufacturing innovation and automation which limits its potential to …