An analysis of genetic heterogeneity in untreated cancers
Genetic intratumoural heterogeneity is a natural consequence of imperfect DNA replication.
Any two randomly selected cells, whether normal or cancerous, are therefore genetically …
Any two randomly selected cells, whether normal or cancerous, are therefore genetically …
Hacking the cancer genome: profiling therapeutically actionable long non-coding RNAs using CRISPR-Cas9 screening
Long non-coding RNAs (lncRNAs) represent a huge reservoir of potential cancer targets.
Such" onco-lncRNAs" have resisted traditional RNAi methods, but CRISPR-Cas9 genome …
Such" onco-lncRNAs" have resisted traditional RNAi methods, but CRISPR-Cas9 genome …
Discovery of common and rare genetic risk variants for colorectal cancer
To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …
Identification of cancer driver genes based on nucleotide context
Cancer genomes contain large numbers of somatic mutations but few of these mutations
drive tumor development. Current approaches either identify driver genes on the basis of …
drive tumor development. Current approaches either identify driver genes on the basis of …
A practical framework and online tool for mutational signature analyses show intertissue variation and driver dependencies
A Degasperi, TD Amarante, J Czarnecki, S Shooter… - Nature cancer, 2020 - nature.com
Mutational signatures are patterns of mutations that arise during tumorigenesis. We present
an enhanced, practical framework for mutational signature analyses. Applying these …
an enhanced, practical framework for mutational signature analyses. Applying these …
The U1 spliceosomal RNA is recurrently mutated in multiple cancers
Cancers are caused by genomic alterations known as drivers. Hundreds of drivers in coding
genes are known but, to date, only a handful of noncoding drivers have been discovered …
genes are known but, to date, only a handful of noncoding drivers have been discovered …
The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic
Esophageal adenocarcinoma (EAC) is a poor-prognosis cancer type with rapidly rising
incidence. Understanding of the genetic events driving EAC development is limited, and …
incidence. Understanding of the genetic events driving EAC development is limited, and …
A pan-cancer transcriptome analysis reveals pervasive regulation through alternative promoters
Most human protein-coding genes are regulated by multiple, distinct promoters, suggesting
that the choice of promoter is as important as its level of transcriptional activity. However …
that the choice of promoter is as important as its level of transcriptional activity. However …
[HTML][HTML] Local determinants of the mutational landscape of the human genome
Large-scale chromatin features, such as replication time and accessibility influence the rate
of somatic and germline mutations at the megabase scale. This article reviews how local …
of somatic and germline mutations at the megabase scale. This article reviews how local …
An integrative ENCODE resource for cancer genomics
ENCODE comprises thousands of functional genomics datasets, and the encyclopedia
covers hundreds of cell types, providing a universal annotation for genome interpretation …
covers hundreds of cell types, providing a universal annotation for genome interpretation …