The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome
from single cells is transforming our understanding of cell biology in health and disease. In …

Single-cell multi-omics technologies and methods characterize cell states and activities by
simultaneously integrating various single-modality omics methods that profile the …

In the last decade, single-cell RNA sequencing routinely performed on large numbers of
single cells has greatly advanced our understanding of the underlying heterogeneity of …

Recent technological advances have enabled massively parallel chromatin profiling with
scATAC-seq (single-cell assay for transposase accessible chromatin by sequencing). Here …

Advances in single-cell isolation and barcoding technologies offer unprecedented
opportunities to profile DNA, mRNA, and proteins at a single-cell resolution. Recently, bulk …

Cell function and activity are regulated through integration of signaling, epigenetic,
transcriptional, and metabolic pathways. Here, we introduce INs-seq, an integrated …

Identifying gene-regulatory targets of nuclear proteins in tissues is a challenge. Here we
describe intranuclear cellular indexing of transcriptomes and epitopes (inCITE-seq), a …

Single-cell transcriptomic approaches have revolutionised the study of complex biological
systems, with the routine measurement of gene expression in thousands of cells enabling …

Single-cell RNA genomics technologies are revolutionizing biomedical science by profiling
single cells with unprecedented resolution, providing fundamental insights into the role of …

In this work, we describe NEAT-seq (sequencing of nuclear protein epitope abundance,
chromatin accessibility and the transcriptome in single cells), enabling interrogation of …