Bile acids (BAs) can regulate their own metabolism and transport as well as other key
aspects of metabolic homeostasis via dedicated (nuclear and G protein-coupled) receptors …

Over the past two decades, bile acids (BAs) have become established as important
signaling molecules that enable fine-tuned inter-tissue communication from the liver, their …

Sepsis and septic shock are characterized by life-threatening organ dysfunction caused by a
dysregulated host response to infection. The liver has a central role during sepsis, and is …

The close relationship between primary sclerosing cholangitis (PSC) and inflammatory
bowel disease (IBD) provides a good opportunity to comprehend the gut–liver axis. The gut …

CTNNB1 mutations activating ß‐catenin are frequent somatic events in hepatocellular
carcinoma (HCC) and adenoma (HCA), particularly associated with a risk of malignant …

Fibrosis is a chronic and progressive disorder characterized by excessive deposition of
extracellular matrix, which leads to scarring and loss of function of the affected organ or …

In the last 25 years, a number of animal models, mainly rodents, have been generated with
the goal to mimic cholestatic liver injuries and, thus, to provide in vivo tools to investigate the …

Xenobiotics and drugs may lead to cholangiopathies and biliary fibrosis, but the underlying
mechanisms are largely unknown. Therefore, we aimed to characterize the cause and …

Cholangiocytes are biliary epithelial cells, which, like hepatocytes, originate from
hepatoblasts during embryonic development. In this study we investigated the potential of …

Recent progress in basic research has enhanced our understanding of the molecular
mechanisms of normal bile secretion and their alterations in cholestasis. Genetic transporter …