[HTML][HTML] Homologous recombination deficiency (HRD) testing landscape: clinical applications and technical validation for routine diagnostics

A Witz, J Dardare, M Betz, C Michel… - Biomarker …, 2025 - pmc.ncbi.nlm.nih.gov
The use of poly (ADP-ribose) polymerase inhibitors (PARPi) revolutionized the treatment of
BRCA-mutated cancers. Identifying patients exhibiting homologous recombination …

GIInger predicts homologous recombination deficiency and patient response to PARPi treatment from shallow genomic profiles

C Pozzorini, G Andre, T Coletta, A Buisson, J Bieler… - Cell Reports …, 2023 - cell.com
Homologous recombination deficiency (HRD) is a predictive biomarker for poly (ADP-ribose)
polymerase 1 inhibitor (PARPi) sensitivity. Routine HRD testing relies on identifying BRCA …

Homologous recombination deficiency (HRD) testing on cell-free tumor DNA from peritoneal fluid

C Roussel-Simonin, F Blanc-Durand, R Tang… - Molecular Cancer, 2023 - Springer
Background Knowing the homologous recombination deficiency (HRD) status in advanced
epithelial ovarian cancer (EOC) is vital for patient management. HRD is determined by …

Can Morphology and Immune Infiltration Predict the Homologous Recombination Deficiency Status in Newly Diagnosed High-Grade Serous Ovarian Carcinoma …

A Kime, G Bataillon, I Treilleux… - … of Pathology & …, 2024 - meridian.allenpress.com
Context.—A correlation between the morphology of ovarian high-grade serous carcinomas
(HGSOCs) and BRCA mutations has been previously reported. Objective.—To investigate …

The Molecular Classification of Ovarian Cancer and Implication for Treatment

M Kossaï, M Cavaille, F Penault-Llorca - … of the Ovary, Fallopian Tube and …, 2024 - Springer
Ovarian cancers are divided into epithelial carcinomas, representing the majority of
malignant ovarian tumours in adult women (90%) and non-epithelial carcinomas. In each …

of Ovarian Cancer and Implication

M Kossaï, M Cavaille… - Pathology of the Ovary …, 2023 - books.google.com
Ovarian cancers are divided into epithelial carcinomas, representing the majority of
malignant ovarian tumours in adult women (90%) and non-epithelial carcinomas. In each …