The lipids that make up biological membranes tend to be the forgotten molecules of cell
biology. The paucity of data on these important entities likely reflects the difficulties of …

Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity worldwide
leading to 31% of all global deaths. Early prediction and prevention could greatly reduce the …

The challenge of precision medicine is to model complex interactions among DNA variants,
phenotypes, development, environments, and treatments. We address this challenge by …

Understanding genetic architecture of plasma lipidome could provide better insights into
lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome …

Studies in preclinical models suggest that complex lipids, such as phospholipids, play a role
in the regulation of longevity. However, identification of universally conserved complex lipid …

Dysregulation of lipid homeostasis is a precipitating event in the pathogenesis and
progression of hepatosteatosis and metabolic syndrome. These conditions are highly …

Lipids in bovine milk have several biological activities, with implications for human health
and the physical functionality of foods. However, alterations in the lipid profile of bovine milk …

Background Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder
(ASD) are neurodevelopmental conditions with early life origins. Alterations in blood lipids …

Mouse models have been instrumental in understanding human disease biology and
proposing possible new treatments. The precise control of the environment and genetic …

Despite the crucial roles of lipids in metabolism, we are still at the early stages of
comprehensively annotating lipid species and their genetic basis. Mass spectrometry–based …