Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond
Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …
Endoreplication: polyploidy with purpose
A great many cell types are necessary for the myriad capabilities of complex, multicellular
organisms. One interesting aspect of this diversity of cell type is that many cells in diploid …
organisms. One interesting aspect of this diversity of cell type is that many cells in diploid …
The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors
Platelets are critical for haemostasis, thrombosis, and inflammatory responses,, but the
events that lead to mature platelet production remain incompletely understood. The bone …
events that lead to mature platelet production remain incompletely understood. The bone …
[HTML][HTML] The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism
Mixed lineage kinase domain-like (MLKL) is a component of the" necrosome," the
multiprotein complex that triggers tumor necrosis factor (TNF)-induced cell death by …
multiprotein complex that triggers tumor necrosis factor (TNF)-induced cell death by …
Eltrombopag added to standard immunosuppression for aplastic anemia
Background Acquired aplastic anemia results from immune-mediated destruction of bone
marrow. Immunosuppressive therapies are effective, but reduced numbers of residual stem …
marrow. Immunosuppressive therapies are effective, but reduced numbers of residual stem …
[BOOK][B] Wintrobe's clinical hematology
MM Wintrobe - 2008 - books.google.com
Now available in a thoroughly revised Twelfth Edition, Wintrobe's Clinical Hematology
continues to be an industry leader with its ability to correlate basic science with the clinical …
continues to be an industry leader with its ability to correlate basic science with the clinical …
Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche
H Yoshihara, F Arai, K Hosokawa, T Hagiwara… - Cell stem cell, 2007 - cell.com
Maintenance of hematopoietic stem cells (HSCs) depends on interaction with their niche.
Here we show that the long-term (LT)-HSCs expressing the thrombopoietin (THPO) receptor …
Here we show that the long-term (LT)-HSCs expressing the thrombopoietin (THPO) receptor …
Eltrombopag and improved hematopoiesis in refractory aplastic anemia
Background Severe aplastic anemia, which is characterized by immune-mediated bone
marrow hypoplasia and pancytopenia, can be treated effectively with immunosuppressive …
marrow hypoplasia and pancytopenia, can be treated effectively with immunosuppressive …
Upregulation of Flt3 expression within the bone marrow Lin− Sca1+ c-kit+ stem cell compartment is accompanied by loss of self-renewal capacity
Flt3 has emerged as a potential regulator of hematopoietic stem cells (HSC). Sixty percent of
cells in the mouse marrow Lin− Sca1+ c-kit+ HSC pool expressed flt3. Although single cell …
cells in the mouse marrow Lin− Sca1+ c-kit+ HSC pool expressed flt3. Although single cell …
Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells
T Gainsford, TA Willson, D Metcalf… - Proceedings of the …, 1996 - National Acad Sciences
Many cytokines exert their biological effect through members of the hemopoietin receptor
family. Using degenerate oligonucleotides to the common WSXWS motif, we have cloned …
family. Using degenerate oligonucleotides to the common WSXWS motif, we have cloned …