Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …

Modifications in the microbiota caused by environmental and genetic reasons can
unbalance the intestinal homeostasis, deregulating the host's metabolism and immune …

Liver fibrosis is a chronic liver disease with the presence of progressive wound healing
response caused by liver injury. Currently, there are no approved therapies for liver fibrosis …

Nonalcoholic fatty liver disease (NAFLD) is a main hepatic manifestation of metabolic
syndrome. It represents a wide spectrum of histopathological abnormalities ranging from …

The mitochondrial permeability transition pore (MPTP) is a calcium-dependent, ion non-
selective membrane pore with a wide range of functions. Although the MPTP has been …

According to the 'multiple‐hit'hypothesis, several factors can act simultaneously in
nonalcoholic fatty liver disease (NAFLD) progression. Increased nitro‐oxidative (nitroso …

Nonalcoholic fatty liver disease (NAFLD) is today considered the most common form of
chronic liver disease, affecting a high proportion of the population worldwide. NAFLD …

Non-alcoholic fatty liver disease (NAFLD) comprises fatty liver (steatosis), non-alcoholic
steatohepatitis (NASH) and fibrosis/cirrhosis and may lead to end-stage liver failure or …

The worldwide rising prevalence of obesity and insulin resistance is associated with a
parallel increase in nonalcoholic fatty liver disease (NAFLD). NAFLD is characterized by …

NAFLD is a common disease in Western society and ranges from steatosis to steatohepatitis
and to end-stage liver disease. The molecular mechanisms that cause the progression of …