Pathomechanism of intervertebral disc degeneration
T Oichi, Y Taniguchi, Y Oshima, S Tanaka, T Saito - JOR spine, 2020 - Wiley Online Library
Intervertebral disc degeneration (IDD) is the main contributor to low back pain, which is a
leading cause of disability worldwide. Although substantial progress has been made in …
leading cause of disability worldwide. Although substantial progress has been made in …
Intervertebral disc regeneration: from cell therapy to the development of novel bioinspired endogenous repair strategies
Low back pain (LBP), frequently associated with intervertebral disc (IVD) degeneration, is a
major public health concern. LBP is currently managed by pharmacological treatments and …
major public health concern. LBP is currently managed by pharmacological treatments and …
Spatially defined single-cell transcriptional profiling characterizes diverse chondrocyte subtypes and nucleus pulposus progenitors in human intervertebral discs
Y Gan, J He, J Zhu, Z Xu, Z Wang, J Yan, O Hu, Z Bai… - Bone Research, 2021 - nature.com
A comprehensive understanding of the cellular heterogeneity and molecular mechanisms
underlying the development, homeostasis, and disease of human intervertebral disks (IVDs) …
underlying the development, homeostasis, and disease of human intervertebral disks (IVDs) …
[HTML][HTML] Single-cell RNA-seq analysis identifies unique chondrocyte subsets and reveals involvement of ferroptosis in human intervertebral disc degeneration
Y Zhang, S Han, M Kong, Q Tu, L Zhang, X Ma - Osteoarthritis and cartilage, 2021 - Elsevier
Objective Nucleus pulposus (NP) plays a central role in disc degeneration pathogenesis,
however, as a heterogeneous tissue, cell subsets in NP and their corresponding biological …
however, as a heterogeneous tissue, cell subsets in NP and their corresponding biological …
IVD progenitor cells: a new horizon for understanding disc homeostasis and repair
FJ Lyu, KM Cheung, Z Zheng, H Wang… - Nature Reviews …, 2019 - nature.com
Intervertebral disc (IVD) degeneration is associated with low back pain. In IVDs, a high
mechanical load, high osmotic pressure and hypoxic conditions create a hostile …
mechanical load, high osmotic pressure and hypoxic conditions create a hostile …
Mesenchymal stromal/stem cells and their exosomes application in the treatment of intervertebral disc disease: A promising frontier
G Widjaja, AT Jalil, HS Budi, WK Abdelbasset… - International …, 2022 - Elsevier
Today, the application of mesenchymal stromal/stem cells (MSCs) and their exosomes to
treat degenerative diseases has received attention. Due to the characteristics of these cells …
treat degenerative diseases has received attention. Due to the characteristics of these cells …
Intervertebral disc human nucleus pulposus cells associated with back pain trigger neurite outgrowth in vitro and pain behaviors in rats
Low back pain (LBP) is often associated with the degeneration of human intervertebral discs
(IVDs). However, the pain-inducing mechanism in degenerating discs remains to be …
(IVDs). However, the pain-inducing mechanism in degenerating discs remains to be …
Human induced pluripotent stem cells differentiate into functional mesenchymal stem cells and repair bone defects
Mesenchymal stem cells (MSCs) are currently the most established cells for skeletal tissue
engineering and regeneration; however, their availability and capability of self-renewal are …
engineering and regeneration; however, their availability and capability of self-renewal are …
Ferroptosis: A potential target for the intervention of intervertebral disc degeneration
LP Zhou, RJ Zhang, CY Jia, L Kang… - Frontiers in …, 2022 - frontiersin.org
Ferroptosis, an iron-dependent form of programmed cell death marked by phospholipid
peroxidation, is regulated by complex cellular metabolic pathways including lipid …
peroxidation, is regulated by complex cellular metabolic pathways including lipid …
[HTML][HTML] Human iPSCs can be differentiated into notochordal cells that reduce intervertebral disc degeneration in a porcine model
Introduction: As many as 80% of the adult population experience back pain at some point in
their lifetimes. Previous studies have indicated a link between back pain and intervertebral …
their lifetimes. Previous studies have indicated a link between back pain and intervertebral …