Lung cancer is one of the most frequently diagnosed cancers and is the leading cause of
cancer-related death worldwide. Non-small-cell lung cancer (NSCLC), a heterogeneous …

It is generally accepted that metabolism is able to shape the immune response. Only
recently we are gaining awareness that the metabolic crosstalk between different tumor …

Highlights•First FDA approvals for anti-PD-1 antibodies for patients with metastatic
melanoma.•Promising response from ongoing clinical trials with several anti-PD-1/L1 …

Background Lung cancer is one of the leading causes of cancer-related death. At the time of
diagnosis, more than half of the patients will have disseminated disease and, yet …

Cancer immunotherapy has made unprecedented breakthrough in the fields of chimeric
antigen receptor-redirected T (CAR T) cell therapy and immune modulation. Combination of …

Recent studies have highlighted the therapeutic efficacy of immunotherapy, a class of
cancer treatments that utilize the patient's own immune system to destroy cancerous cells …

Lung cancer is the leading cause of cancer mortality and non-small cell lung cancer
(NSCLC) accounts for more than 85% of all lung cancers. Platinum-based doublet …

New insight on the interaction between the immune system and tumor has identified the
programmed death-1/programmed death-1 ligand pathway to be a key player in evading …

Cytochromes are expressed in many different tissues of the human body. They are found
mostly in intestinal and hepatic tissues. Cytochromes P450 (CYPs) are enzymes that oxidize …

In recent years immune checkpoint inhibitors have garnered attention as being one of the
most promising types of immunotherapy on the horizon. There has been particular focus on …