The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …

Scientists in this field often joke," If you don't have a mechanism, say it's ROS." Seemingly
connected to every biological process ever described, reactive oxygen species (ROS) have …

Cancer cells depend on nicotinamide adenine dinucleotide phosphate (NADPH) to combat
oxidative stress and support reductive biosynthesis. One major NADPH production route is …

Melanin synthesis involves the successful coordination of metabolic pathways across
multiple intracellular compartments including the melanosome, mitochondria, ER/Golgi, and …

Ferroptosis is the type of cell death arising from uncontrolled and excessive lipid
peroxidation. NADPH is essential for ferroptosis regulation because it supplies reducing …

Glucose-6-phosphate dehydrogenase (G6PD) is the only rate-limiting enzyme in the
pentose phosphate pathway (PPP). Rapidly proliferating cells require metabolites from PPP …

Mitochondria are critical for proper organ function and mechanisms to promote
mitochondrial health during regeneration would benefit tissue homeostasis. We report that …

Rampant phospholipid peroxidation initiated by iron causes ferroptosis unless this is
restrained by cellular defences. Ferroptosis is increasingly implicated in a host of diseases …

Metastasis is responsible for 90% of deaths in patients with cancer. Understanding the role
of metabolism during metastasis has been limited by the development of robust and …

The blast fungus Magnaporthe oryzae produces invasive hyphae in living rice cells during
early infection, separated from the host cytoplasm by plant-derived interfacial membranes …