Zinc in cardiovascular functions and diseases: epidemiology and molecular mechanisms for therapeutic development

T Hara, E Yoshigai, T Ohashi, T Fukada - International journal of …, 2023 - mdpi.com
Zinc is an essential trace element that plays an important physiological role in numerous
cellular processes. Zinc deficiency can result in diverse symptoms, such as impairment of …

Somatic SLC30A1 mutations altering zinc transporter ZnT1 cause aldosterone-producing adenomas and primary aldosteronism

J Rege, S Bandulik, K Nanba, C Kosmann… - Nature Genetics, 2023 - nature.com
Primary aldosteronism (PA) is the most common form of endocrine hypertension and is
characterized by inappropriately elevated aldosterone production via a renin-independent …

The role of Zn2+ in sha** intracellular Ca2+ dynamics in the heart

AM Dorward, AJ Stewart, SJ Pitt - Journal of General Physiology, 2023 - rupress.org
Increasing evidence suggests that Zn2+ acts as a second messenger capable of
transducing extracellular stimuli into intracellular signaling events. The importance of Zn2+ …

Atrial fibrillation hospitalization is not increased with short‐term elevations in exposure to fine particulate air pollution

TJ Bunch, BD Horne, SJ Asirvatham… - Pacing and clinical …, 2011 - Wiley Online Library
Background: Previous studies have observed that short‐term exposure to elevated
concentrations of particulate matter (PM) air pollution increases risk of acute ischemic heart …

Why is it worth testing the ability of zinc to protect against ischaemia reperfusion injury for human application

J Ischia, DM Bolton, O Patel - Metallomics, 2019 - academic.oup.com
Ischaemia (interruption in the blood/oxygen supply) and subsequent damage induced by
reperfusion (restoration of blood/oxygen supply) ultimately leads to cell death, tissue injury …

An increase in intercellular crosstalk and electrotonic coupling between cardiomyocytes and nonmyocytes reshapes the electrical conduction in the metabolic heart …

D Billur, Y Olgar, A Durak, AH Yozgat… - Cell biochemistry …, 2023 - Wiley Online Library
Cardiac conduction abnormalities are disorders in metabolic syndrome (MetS), however,
their mechanisms are unknown. Although ventricular arrhythmia reflects the changes in QT …

Proarrhythmic atrial calcium cycling in the diseased heart

N Voigt, S Nattel, D Dobrev - Calcium Signaling, 2012 - Springer
During the last decades Ca 2+ has been found to play a crucial role in cardiac arrhythmias
associated with heart failure and a number of congenital arrhythmia syndromes. Recent …

Zinc transporter somatic gene mutations cause primary aldosteronism

J Rege, K Nanba, S Bandulik, C Kosmann, AR Blinder… - bioRxiv, 2022 - biorxiv.org
Primary aldosteronism (PA) is the most common form of endocrine hypertension and effects
one in 50 adults. PA is characterized by inappropriately elevated aldosterone production via …

The environmental epidemiology of atrial arrhythmogenesis

EA Whitsel, CL Avery - Journal of Epidemiology & Community Health, 2010 - jech.bmj.com
Atrial fibrillation (AF) is the most common cardiac arrhythmia seen in clinical practice, and
makes an important contribution to cardiovascular disease (CVD) and all-cause mortality …

Oxidative Stress and Labile Zinc in Heart Dysfunction Under Hyperglycemia

B Turan - Oxidative Stress in Heart Diseases, 2019 - Springer
Three major biological roles of zinc (as Zn 2+) in several proteins and enzymes, including
the catalytic, structural and regulatory, brings Zn 2+ to be an important signaling molecule …