Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …

The rapid growth of high-throughput technologies has transformed biomedical research.
With the increasing amount and complexity of data, scalability and reproducibility have …

Pangenome references address biases of reference genomes by storing a representative
set of diverse haplotypes and their alignment, usually as a graph. Alternate alleles …

Proteolysis-targeting chimera (PROTAC) and other targeted protein degradation (TPD)
molecules that induce degradation by the ubiquitin-proteasome system (UPS) offer new …

The clinical use of molecular targeted therapy is rapidly evolving but has primarily focused
on genomic alterations. Transcriptomic analysis offers an opportunity to dissect the …

Data analysis often entails a multitude of heterogeneous steps, from the application of
various command line tools to the usage of scripting languages like R or Python for the …

Tumor-infiltrating myeloid cells (TIMs) are key regulators in tumor progression, but the
similarity and distinction of their fundamental properties across different tumors remain …

Malignant tumors exhibit heterogeneous metabolic reprogramming, hindering the
identification of translatable vulnerabilities for metabolism-targeted therapy. How molecular …

To the Editor—There is a great need for easy-to-use cancer genomics visualization tools for
both large public data resources such as TCGA (The Cancer Genome Atlas) 1 and the GDC …

Brain malignancies encompass a range of primary and metastatic cancers, including low-
grade and high-grade gliomas and brain metastases (BrMs) originating from diverse …