Hyperekplexia is a rare neurological disorder characterized by neonatal hypertonia,
exaggerated startle responses to unexpected stimuli and a variable incidence of apnoea …

Ionotropic glycine receptors (GlyRs) enable fast synaptic neurotransmission in the adult
spinal cord and brainstem. The inhibitory GlyR is a transmembrane glycine-gated chloride …

Objective Impairment of glycinergic neurotransmission leads to complex movement and
behavioral disorders. Patients harboring glycine receptor autoantibodies suffer from stiff …

The glycine receptor (GlyR) is a pentameric ligand-gated ion channel (pLGIC) mediating
inhibitory transmission in the nervous system. Its transmembrane domain (TMD) is the target …

Glycine receptors (GlyR) conduct inhibitory glycinergic neurotransmission in the spinal cord
and the brainstem. They play an important role in muscle tone, motor coordination …

GABAA receptors are brain inhibitory chloride ion channels. Here we show functional
analyses and structural simulations for three de novo missense mutations in the GABAA …

The family of Cys-loop receptors (CLRs) shares a high degree of homology and sequence
identity. The overall structural elements are highly conserved with a large extracellular …

Recent studies on the pathogenic mechanisms of recessive hyperekplexia indicate
disturbances in glycine receptor (GlyR) α1 biogenesis. Here, we examine the properties of a …

Startle, a basic alerting reaction common to all mammals, is described as a sudden
involuntary movement of the body evoked by all kinds of sudden and unexpected stimulus …

Glycine receptors (GlyRs) containing the α2 subunit regulate cortical interneuron migration.
Disruption of the GlyR α2 subunit gene (Glra2) in mice leads to disrupted dorsal cortical …