Guanylate-binding proteins: mechanisms of pattern recognition and antimicrobial functions
Guanylate-binding proteins (GBPs) are a family of intracellular proteins which have diverse
biological functions, including pathogen sensing and host defense against infectious …
biological functions, including pathogen sensing and host defense against infectious …
Human guanylate-binding proteins in intracellular pathogen detection, destruction, and host cell death induction
Cell-intrinsic defense is an essential part of the immune response against intracellular
pathogens regulated by cytokine-induced proteins and pathways. One of the most …
pathogens regulated by cytokine-induced proteins and pathways. One of the most …
Adipose triglyceride lipase suppresses noncanonical inflammasome by hydrolyzing LPS
W Li, Q Liu, Y Qian, C Wang, C Kong, L Sun… - Nature Chemical …, 2024 - nature.com
Intracellular recognition of lipopolysaccharide (LPS) by mouse caspase-11 or human
caspase-4 is a vital event for the activation of the noncanonical inflammasome. Whether …
caspase-4 is a vital event for the activation of the noncanonical inflammasome. Whether …
Clostridium perfringens virulence factors are nonredundant activators of the NLRP3 inflammasome
Inflammasome signaling is a central pillar of innate immunity triggering inflammation and
cell death in response to microbes and danger signals. Here, we show that two virulence …
cell death in response to microbes and danger signals. Here, we show that two virulence …
Strategies of bacterial detection by inflammasomes
Mammalian innate immunity is regulated by pattern-recognition receptors (PRRs) and guard
proteins, which use distinct strategies to detect infections. PRRs detect bacterial molecules …
proteins, which use distinct strategies to detect infections. PRRs detect bacterial molecules …
Identification and experimental validation of PYCARD as a crucial PANoptosis-related gene for immune response and inflammation in COPD
R Shi, R Liang, F Wang, L Wang, W Zidai, J Zhang… - Apoptosis, 2024 - Springer
Chronic inflammatory and immune responses play key roles in the development and
progression of chronic obstructive pulmonary disease (COPD). PANoptosis, as a unique …
progression of chronic obstructive pulmonary disease (COPD). PANoptosis, as a unique …
Interferon signalling and non-canonical inflammasome activation promote host protection against multidrug-resistant Acinetobacter baumannii
Multidrug-resistant (MDR) Acinetobacter baumannii are of major concern worldwide due to
their resistance to last resort carbapenem and polymyxin antibiotics. To develop an effective …
their resistance to last resort carbapenem and polymyxin antibiotics. To develop an effective …
Mouse guanylate-binding proteins of the chromosome 3 cluster do not mediate antiviral activity in vitro or in mouse models of infection
Dynamin-like GTPase proteins, including myxoma (Mx) and guanylate-binding proteins
(GBPs), are among the many interferon stimulated genes induced following viral infections …
(GBPs), are among the many interferon stimulated genes induced following viral infections …
The intricate interactions between inflammasomes and bacterial pathogens: Roles, mechanisms, and therapeutic potentials
JK Kim, A Sapkota, T Roh, EK Jo - Pharmacology & Therapeutics, 2024 - Elsevier
Inflammasomes are intracellular multiprotein complexes that consist of a sensor, an adaptor,
and a caspase enzyme to cleave interleukin (IL)-1β and IL-18 into their mature forms. In …
and a caspase enzyme to cleave interleukin (IL)-1β and IL-18 into their mature forms. In …
PANEL 3: otitis media animal models, cell culture, tissue regeneration & pathophysiology
Objective To review and summarize recently published key articles on the topics of animal
models, cell culture studies, tissue biomedical engineering and regeneration, and new …
models, cell culture studies, tissue biomedical engineering and regeneration, and new …