Dengue virus and the host innate immune response
N Uno, TM Ross - Emerging microbes & infections, 2018 - Taylor & Francis
Dengue virus (DENV) is a mosquito-borne Flavivirus that is endemic in many tropical and
sub-tropical countries where the transmission vectors Aedes spp. mosquitoes resides. There …
sub-tropical countries where the transmission vectors Aedes spp. mosquitoes resides. There …
The flavivirus NS2B–NS3 protease–helicase as a target for antiviral drug development
The flavivirus NS3 protein is associated with the endoplasmic reticulum membrane via its
close interaction with the central hydrophilic region of the NS2B integral membrane protein …
close interaction with the central hydrophilic region of the NS2B integral membrane protein …
Structure of the NS2B-NS3 protease from Zika virus after self-cleavage
The recent outbreak of Zika virus (ZIKV) infections in the Americas represents a serious
threat to the global public health. The viral protease that processes viral polyproteins during …
threat to the global public health. The viral protease that processes viral polyproteins during …
Structural proteomics of dengue virus
In this paper, we discuss recent advances in our knowledge of the dengue virus life cycle
based on new structural data of the virus and its proteins. Specifically, we focus on the …
based on new structural data of the virus and its proteins. Specifically, we focus on the …
A highly structured, nuclease-resistant, noncoding RNA produced by flaviviruses is required for pathogenicity
GP Pijlman, A Funk, N Kondratieva, J Leung, S Torres… - Cell host & …, 2008 - cell.com
Viral noncoding RNAs have been shown to play an important role in virus-host interplay to
facilitate virus replication. We report that members of the genus Flavivirus, a large group of …
facilitate virus replication. We report that members of the genus Flavivirus, a large group of …
Nucleolus: the fascinating nuclear body
V Sirri, S Urcuqui-Inchima, P Roussel… - Histochemistry and cell …, 2008 - Springer
Nucleoli are the prominent contrasted structures of the cell nucleus. In the nucleolus,
ribosomal RNAs are synthesized, processed and assembled with ribosomal proteins. RNA …
ribosomal RNAs are synthesized, processed and assembled with ribosomal proteins. RNA …
West Nile virus neuroinvasive disease
LE Davis, R DeBiasi, DE Goade… - Annals of Neurology …, 2006 - Wiley Online Library
Since 1999, there have been nearly 20,000 cases of confirmed symptomatic West Nile virus
(WNV) infection in the United States, and it is likely that more than 1 million people have …
(WNV) infection in the United States, and it is likely that more than 1 million people have …
Pathogenesis of West Nile Virus infection: a balance between virulence, innate and adaptive immunity, and viral evasion
West Nile virus (WNV) is a neurotropic ffavivirus that has emerged globally as a significant
cause of viral encephalitis. WNV is maintained in an enzootic cycle between mosquitoes …
cause of viral encephalitis. WNV is maintained in an enzootic cycle between mosquitoes …
Molecular mechanisms associated with neurodegeneration of neurotropic viral infection
P Wongchitrat, T Chanmee, P Govitrapong - Molecular Neurobiology, 2024 - Springer
Viral infections of the central nervous system (CNS) cause variable outcomes from acute to
severe neurological sequelae with increased morbidity and mortality. Viral neuroinvasion …
severe neurological sequelae with increased morbidity and mortality. Viral neuroinvasion …
CRISPR-Cas9 circular permutants as programmable scaffolds for genome modification
The ability to engineer natural proteins is pivotal to a future, pragmatic biology. CRISPR
proteins have revolutionized genome modification, yet the CRISPR-Cas9 scaffold is not …
proteins have revolutionized genome modification, yet the CRISPR-Cas9 scaffold is not …