The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Posttranslational modifications (PTMs) refer to amino acid side chain modification in some
proteins after their biosynthesis. There are more than 400 different types of PTMs affecting …

Protein phosphorylation, catalyzed by protein kinases (PKs), is one of the most important
post-translational modifications (PTMs), and involved in regulating almost all of biological …

We present an r package, ggtree, which provides programmable visualization and
annotation of phylogenetic trees. ggtree can read more tree file formats than other softwares …

Although base editors are widely used to install targeted point mutations, the factors that
determine base editing outcomes are not well understood. We characterized sequence …

3-3 proteins are highly conserved regulatory proteins that interact with hundreds of
structurally diverse clients and act as central hubs of signaling networks. However, how 14-3 …

The ability to identify ovarian cancer (OC) at its earliest stages remains a challenge. The
patients present an advanced stage at diagnosis. This heterogeneous disease has …

In eukaryotes, protein phosphorylation is specifically catalyzed by numerous protein kinases
(PKs), faithfully orchestrates various biological processes, and reversibly determines cellular …

Many infections and stress signals can rapidly activate the NLRP3 inflammasome to elicit
robust inflammatory responses. This activation requires a priming step, which is thought to …

Artificial intelligence (AI) methods have been and are now being increasingly integrated in
prediction software implemented in bioinformatics and its glycoscience branch known as …