Post-translational modifications in proteins: resources, tools and prediction methods
S Ramazi, J Zahiri - Database, 2021 - academic.oup.com
Posttranslational modifications (PTMs) refer to amino acid side chain modification in some
proteins after their biosynthesis. There are more than 400 different types of PTMs affecting …
proteins after their biosynthesis. There are more than 400 different types of PTMs affecting …
Applications of proteomics in ovarian cancer: dawn of a new era
A Ghose, SVN Gullapalli, N Chohan, A Bolina… - Proteomes, 2022 - mdpi.com
The ability to identify ovarian cancer (OC) at its earliest stages remains a challenge. The
patients present an advanced stage at diagnosis. This heterogeneous disease has …
patients present an advanced stage at diagnosis. This heterogeneous disease has …
ggtree: an r package for visualization and annotation of phylogenetic trees with their covariates and other associated data
We present an r package, ggtree, which provides programmable visualization and
annotation of phylogenetic trees. ggtree can read more tree file formats than other softwares …
annotation of phylogenetic trees. ggtree can read more tree file formats than other softwares …
GPS 5.0: an update on the prediction of kinase-specific phosphorylation sites in proteins
In eukaryotes, protein phosphorylation is specifically catalyzed by numerous protein kinases
(PKs), faithfully orchestrates various biological processes, and reversibly determines cellular …
(PKs), faithfully orchestrates various biological processes, and reversibly determines cellular …
Determinants of base editing outcomes from target library analysis and machine learning
Although base editors are widely used to install targeted point mutations, the factors that
determine base editing outcomes are not well understood. We characterized sequence …
determine base editing outcomes are not well understood. We characterized sequence …
NLRP3 phosphorylation is an essential priming event for inflammasome activation
N Song, ZS Liu, W Xue, ZF Bai, QY Wang, J Dai, X Liu… - Molecular cell, 2017 - cell.com
Many infections and stress signals can rapidly activate the NLRP3 inflammasome to elicit
robust inflammatory responses. This activation requires a priming step, which is thought to …
robust inflammatory responses. This activation requires a priming step, which is thought to …
Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …
public health burden worldwide. The most common form of NCD is metabolic diseases …
A central chaperone-like role for 14-3-3 proteins in human cells
D Segal, S Maier, GJ Mastromarco, WW Qian… - Molecular cell, 2023 - cell.com
3-3 proteins are highly conserved regulatory proteins that interact with hundreds of
structurally diverse clients and act as central hubs of signaling networks. However, how 14-3 …
structurally diverse clients and act as central hubs of signaling networks. However, how 14-3 …
Molecular Evolution of Zika Virus during Its Emergence in the 20th Century
Zika virus (ZIKV) is a mosquito-borne flavivirus first isolated in Uganda in 1947. Although
entomological and virologic surveillance have reported ZIKV enzootic activity in diverse …
entomological and virologic surveillance have reported ZIKV enzootic activity in diverse …
Post-translational modifications of G Protein–Coupled receptors control cellular signaling dynamics in space and time
G protein–coupled receptors (GPCRs) are a large family comprising> 800 signaling
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …