A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

P Cruces, J Retamal, DE Hurtado, B Erranz, P Iturrieta… - Critical Care, 2020 - Springer
Deterioration of lung function during the first week of COVID-19 has been observed when
patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) …

Comparison of optimization parametrizations for regional lung compliance estimation using personalized pulmonary poromechanical modeling

C Laville, C Fetita, T Gille, PY Brillet, H Nunes… - … and Modeling in …, 2023 - Springer
Interstitial lung diseases, such as idiopathic pulmonary fibrosis (IPF) or post-COVID-19
pulmonary fibrosis, are progressive and severe diseases characterized by an irreversible …

Upscaling the poroelastic behavior of the lung parenchyma: A finite-deformation micromechanical model

F Concha, DE Hurtado - Journal of the Mechanics and Physics of Solids, 2020 - Elsevier
The lungs are among the most deformable body organs, a mechanical feature that is key to
the vital process of breathing. Current micromechanical constitutive models of the lung …

Whole-lung finite-element models for mechanical ventilation and respiratory research applications

N Avilés-Rojas, DE Hurtado - Frontiers in Physiology, 2022 - frontiersin.org
Mechanical ventilation has been a vital treatment for Covid-19 patients with respiratory
failure. Lungs assisted with mechanical ventilators present a wide variability in their …