Mathematical modeling of biological processes provides deep insights into complex cellular
systems. While quantitative and continuous models such as differential equations have been …

The biomolecules inside or near cells form a complex interacting system. Cellular
phenotypes and behaviors arise from the totality of interactions among the components of …

Given the complexity and interactive nature of biological systems, constructing informative
and coherent network models of these systems and subsequently develo** efficient …

A central goal of systems biology is the construction of predictive models of bio-molecular
networks. Cellular networks of moderate size have been modeled successfully in a …

Bacterial pathogens are often classified by their toxicity and invasiveness. The invasiveness
of a given bacterium is determined by how capable the bacterium is at invading a broad …

Understanding signal transduction in cellular systems is a central issue in systems biology.
Numerous experiments from different laboratories generate an abundance of individual …

The emerging discipline of Quantitative Systems Pharmacology (QSP) enables the
integration of quantitative experimental data describing the interactions between the various …

Co-infections alter the host immune response but how the systemic and local processes at
the site of infection interact is still unclear. The majority of studies on co-infections …

Background Mathematical modeling of biological regulatory networks provides valuable
insights into the structural and dynamical properties of the underlying systems. While …

Background Aspergillus fumigatus is a ubiquitous airborne fungal pathogen that presents a
life-threatening health risk to individuals with weakened immune systems. A. fumigatus …