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Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
Ancient DNA analysis
Although the first ancient DNA molecules were extracted more than three decades ago, the
first ancient nuclear genomes could only be characterized after high-throughput sequencing …
first ancient nuclear genomes could only be characterized after high-throughput sequencing …
The Allen Ancient DNA Resource (AADR) a curated compendium of ancient human genomes
S Mallick, A Micco, M Mah, H Ringbauer, I Lazaridis… - Scientific Data, 2024 - nature.com
More than two hundred papers have reported genome-wide data from ancient humans.
While the raw data for the vast majority are fully publicly available testifying to the …
While the raw data for the vast majority are fully publicly available testifying to the …
On the limits of fitting complex models of population history to f-statistics
Our understanding of population history in deep time has been assisted by fitting admixture
graphs (AGs) to data: models that specify the ordering of population splits and mixtures …
graphs (AGs) to data: models that specify the ordering of population splits and mixtures …
A global catalog of whole-genome diversity from 233 primate species
The rich diversity of morphology and behavior displayed across primate species provides an
informative context in which to study the impact of genomic diversity on fundamental …
informative context in which to study the impact of genomic diversity on fundamental …
Genomic inference of a severe human bottleneck during the Early to Middle Pleistocene transition
Population size history is essential for studying human evolution. However, ancient
population size history during the Pleistocene is notoriously difficult to unravel. In this study …
population size history during the Pleistocene is notoriously difficult to unravel. In this study …
[HTML][HTML] A disease-associated gene desert directs macrophage inflammation through ETS2
CT Stankey, C Bourges, LM Haag, T Turner-Stokes… - Nature, 2024 - nature.com
Increasing rates of autoimmune and inflammatory disease present a burgeoning threat to
human health. This is compounded by the limited efficacy of available treatments and high …
human health. This is compounded by the limited efficacy of available treatments and high …
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
Neanderthal brains were similar in size to those of modern humans. We sought to
investigate potential differences in neurogenesis during neocortex development. Modern …
investigate potential differences in neurogenesis during neocortex development. Modern …
The major genetic risk factor for severe COVID-19 is inherited from Neanderthals
A recent genetic association study identified a gene cluster on chromosome 3 as a risk locus
for respiratory failure after infection with severe acute respiratory syndrome coronavirus 2 …
for respiratory failure after infection with severe acute respiratory syndrome coronavirus 2 …
[HTML][HTML] The revolution that still isn't: The origins of behavioral complexity in Homo sapiens
EML Scerri, M Will - Journal of Human Evolution, 2023 - Elsevier
The behavioral origins of Homo sapiens can be traced back to the first material culture
produced by our species in Africa, the Middle Stone Age (MSA). Beyond this broad …
produced by our species in Africa, the Middle Stone Age (MSA). Beyond this broad …