Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution

AA Pollen, U Kilik, CB Lowe, JG Camp - Nature Reviews Genetics, 2023 - nature.com
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

Ancient DNA analysis

L Orlando, R Allaby, P Skoglund… - Nature reviews …, 2021 - nature.com
Although the first ancient DNA molecules were extracted more than three decades ago, the
first ancient nuclear genomes could only be characterized after high-throughput sequencing …

The Allen Ancient DNA Resource (AADR) a curated compendium of ancient human genomes

S Mallick, A Micco, M Mah, H Ringbauer, I Lazaridis… - Scientific Data, 2024 - nature.com
More than two hundred papers have reported genome-wide data from ancient humans.
While the raw data for the vast majority are fully publicly available testifying to the …

On the limits of fitting complex models of population history to f-statistics

R Maier, P Flegontov, O Flegontova, U Işıldak… - Elife, 2023 - elifesciences.org
Our understanding of population history in deep time has been assisted by fitting admixture
graphs (AGs) to data: models that specify the ordering of population splits and mixtures …

A global catalog of whole-genome diversity from 233 primate species

LFK Kuderna, H Gao, MC Janiak, M Kuhlwilm, JD Orkin… - Science, 2023 - science.org
The rich diversity of morphology and behavior displayed across primate species provides an
informative context in which to study the impact of genomic diversity on fundamental …

Genomic inference of a severe human bottleneck during the Early to Middle Pleistocene transition

W Hu, Z Hao, P Du, F Di Vincenzo, G Manzi, J Cui… - Science, 2023 - science.org
Population size history is essential for studying human evolution. However, ancient
population size history during the Pleistocene is notoriously difficult to unravel. In this study …

[HTML][HTML] A disease-associated gene desert directs macrophage inflammation through ETS2

CT Stankey, C Bourges, LM Haag, T Turner-Stokes… - Nature, 2024 - nature.com
Increasing rates of autoimmune and inflammatory disease present a burgeoning threat to
human health. This is compounded by the limited efficacy of available treatments and high …

Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals

A Pinson, L **ng, T Namba, N Kalebic, J Peters… - Science, 2022 - science.org
Neanderthal brains were similar in size to those of modern humans. We sought to
investigate potential differences in neurogenesis during neocortex development. Modern …

The major genetic risk factor for severe COVID-19 is inherited from Neanderthals

H Zeberg, S Pääbo - Nature, 2020 - nature.com
A recent genetic association study identified a gene cluster on chromosome 3 as a risk locus
for respiratory failure after infection with severe acute respiratory syndrome coronavirus 2 …

[HTML][HTML] The revolution that still isn't: The origins of behavioral complexity in Homo sapiens

EML Scerri, M Will - Journal of Human Evolution, 2023 - Elsevier
The behavioral origins of Homo sapiens can be traced back to the first material culture
produced by our species in Africa, the Middle Stone Age (MSA). Beyond this broad …