The central nervous system (CNS) and the immune system are both intricate and highly
organized systems that regulate the entire body, with both sharing certain common features …

We tested a newly described molecular memory system, CCR5 signaling, for its role in
recovery after stroke and traumatic brain injury (TBI). CCR5 is uniquely expressed in cortical …

Systemic transplantation of oxygen− glucose deprivation (OGD)-preconditioned primary
microglia enhances neurological recovery in rodent stroke models, albeit the underlying …

Abstract The Stimulator of Interferon Genes (STING) pathway initiates potent immune
responses upon recognition of DNA. To initiate signaling, serine 365 (S365) in the C …

Stroke elicits excessive immune activation in the injured brain tissue. This well-recognized
neural inflammation in the brain is not just an intrinsic organ response but also a result of …

Drug targeting to inflammatory brain pathologies such as stroke and traumatic brain injury
remains an elusive goal. Using a mouse model of acute brain inflammation induced by local …

Intracerebral hemorrhage (ICH) induces a strong hematoma-related neuroinflammatory
reaction and alters peripheral immune homeostasis. Recent research has found that gut …

Age-associated microglial dysfunction contributes to the accumulation of amyloid-β (Aβ)
plaques in Alzheimer's disease. Although several studies have shown age-related declines …

Ex vivo-loaded white blood cells (WBC) can transfer cargo to pathological foci in the central
nervous system (CNS). Here we tested affinity ligand driven in vivo loading of WBC in order …

Chimeric antigen receptor (CAR) T cell therapy in glioblastoma faces many challenges
including insufficient CAR T cell abundance and antigen-negative tumor cells evading …