Tumor microenvironment as a complex milieu driving cancer progression: a mini review

Z Li, J Li, X Bai, X Huang, Q Wang - Clinical and Translational Oncology, 2024 - Springer
It has been spotlighted that the Tumor Microenvironment (TME) is crucial for comprehending
cancer progression and therapeutic resistance. Therefore, this comprehensive review …

[HTML][HTML] Epithelial-mesenchymal transition in cancer: A focus on itraconazole, a hedgehog inhibitor

AM Kulkarni, PKR Gayam, BT Baby… - Biochimica et Biophysica …, 2025 - Elsevier
Cancer, and the resulting mortality from it, is an ever-increasing concern in global health.
Cancer mortality stems from the metastatic progression of the disease, by dissemination of …

Inhibition of nucleo-cytoplasmic proteasome translocation by the aromatic amino acids or silencing Sestrin3—their sensing mediator—is tumor suppressive

I Livneh, B Fabre, G Goldhirsh, C Lulu… - Cell Death & …, 2024 - nature.com
The proteasome, the catalytic arm of the ubiquitin system, is regulated via its dynamic
compartmentation between the nucleus and the cytoplasm, among other mechanisms …

Coagulation-Targeted TGF-β Signaling Pathway Inhibitor Nanomedicine for Inhibiting the Growth and Lung Metastasis of Breast Cancer

Y Xu, J Lv, Y Liu, J Du, C Luo, Y Wang, L Liu… - Nano Letters, 2024 - ACS Publications
The transforming growth factor β (TGF-β) signaling pathway exerts a dual role in
oncogenesis, acting as a suppressor in healthy and early stage neoplastic tissues while …

Physics solves a training problem for artificial neural networks

D Querlioz - 2024 - nature.com
Physics solves a training problem for artificial neural networks Skip to main content Thank you
for visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

[HTML][HTML] Basement membranes in lung metastasis growth and progression

I Torre-Cea, P Berlana-Galán, E Guerra-Paes… - Matrix Biology, 2024 - Elsevier
The lung is a highly vascularized tissue that often harbors metastases from various
extrathoracic malignancies. Lung parenchyma consists of a complex network of alveolar …

Cancer spread in the liver is unlocked from within

K Woess, D Alonso-Curbelo - 2024 - nature.com
Cancer spread in the liver is unlocked from within Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Assessing the metastatic potential of circulating tumor cells using an organ-on-chip model

KF Schmid, S Zeinali, SK Moser, C Dubey… - … in Bioengineering and …, 2024 - frontiersin.org
Metastatic lung cancer remains a leading cause of death worldwide, with its intricate
metastatic cascade posing significant challenges to researchers and clinicians. Despite …

Modeling development of breast cancer: from tumor microenvironment to preclinical applications

R Tang, XQ Liu - Frontiers in Pharmacology, 2024 - frontiersin.org
Breast cancer is a complex disease and its progression is related not only to tumor cells but
also to its microenvironment, which can not be sufficiently reflected by the traditional …

The metastatic cascade through the lens of therapeutic inhibition

I Miranda, N Jahan, LA Shevde - Cell Reports Medicine, 2024 - cell.com
Metastasis is a main cause of cancer-related death, and a deeper understanding of the
metastatic process will inform more targeted and mechanistic approaches that can abrogate …