The immune response and immunopathology of COVID-19

E Mortaz, P Tabarsi, M Varahram, G Folkerts… - Frontiers in …, 2020‏ - frontiersin.org
Coronaviruses were first discovered in the 1960s and are named due to their crown-like
shape. Sometimes, but not often, a coronavirus can infect both animals and humans. An …

Dipeptidyl peptidase 4 inhibitors and their potential immune modulatory functions

S Shao, QQ Xu, X Yu, R Pan, Y Chen - Pharmacology & therapeutics, 2020‏ - Elsevier
Abstract Dipeptidyl peptidase 4 (DPP4) inhibitors (DPP4is) are oral anti-diabetic drugs
(OADs) for the treatment of type 2 diabetes mellitus (T2DM) through inhibiting the …

Sitagliptin treatment at the time of hospitalization was associated with reduced mortality in patients with type 2 diabetes and COVID-19: a multicenter, case-control …

SB Solerte, F D'Addio, R Trevisan, E Lovati… - Diabetes …, 2020‏ - diabetesjournals.org
OBJECTIVE Poor outcomes have been reported in patients with type 2 diabetes and
coronavirus disease 2019 (COVID-19); thus, it is mandatory to explore novel therapeutic …

A systematic review on the functional role of Th1/Th2 cytokines in type 2 diabetes and related metabolic complications

T Mahlangu, PV Dludla, TM Nyambuya, V Mxinwa… - Cytokine, 2020‏ - Elsevier
Abstract The T-helper (Th1/Th2) paradigm is widely studied for its role in modulating an
adaptive immune response, especially in relation to the onset of various autoimmune …

Depletion of polyfunctional CD26highCD8+ T cells repertoire in chronic lymphocytic leukemia

N Bozorgmehr, M Hnatiuk, AC Peters… - Experimental hematology & …, 2023‏ - Springer
Background CD8+ T cells play an essential role against tumors but the role of human CD8+
CD26+ T cell subset against tumors, in particular, haematological cancers such as chronic …

Cytokine storm modulation in COVID-19: a proposed role for vitamin D and DPP-4 inhibitor combination therapy (VIDPP-4i)

MM Pinheiro, A Fabbri, M Infante - Immunotherapy, 2021‏ - Taylor & Francis
A dysregulated immune response characterized by the hyperproduction of several pro-
inflammatory cytokines (aka 'cytokine storm') plays a central role in the pathophysiology of …

Targeting SARS-CoV-2 receptors as a means for reducing infectivity and improving antiviral and immune response: an algorithm-based method for overcoming …

R Gelman, A Bayatra, A Kessler… - Emerging microbes & …, 2020‏ - Taylor & Francis
The ongoing severe acute respiratory syndrome pandemic caused by the novel coronavirus
2 (SARS-CoV-2) is associated with high morbidity and mortality rates, and it has created a …

The role of dipeptidyl peptidase‐4 in cutaneous disease

PM Patel, VA Jones, K Kridin… - Experimental …, 2021‏ - Wiley Online Library
Abstract Dipeptidyl peptidase‐4 (DPP4) is a multifunctional, transmembrane glycoprotein
present on the cell surface of various tissues. It is present in multiple molecular forms …

Neopterin and biopterin levels and tryptophan degradation in patients with diabetes

S Gürcü, G Girgin, G Yorulmaz, B Kılıçarslan, B Efe… - Scientific reports, 2020‏ - nature.com
This study aimed to evaluate the possible changes of neopterin, biopterin levels and
tryptophan degradation in diabetes and to compare the results within diabetes groups and …

Neuroprotective activity of sitagliptin via reduction of neuroinflammation beyond the incretin effect: Focus on Alzheimer's disease

M Wiciński, E Wódkiewicz, M Słupski… - BioMed Research …, 2018‏ - Wiley Online Library
Sitagliptin is a member of a class of drugs that inhibit dipeptidyl peptidase (DPP‐4). It
increases the levels of the active form of incretins such as GLP‐1 (glucagon‐like peptide‐1) …