Carcinoid tumors are rare, slow-growing neuroendocrine tumors arising from the
enterochromaffin cells disseminated throughout the gastrointestinal and bronchopulmonary …

Currently, there is no completely effective therapy available for metastatic
phaeochromocytomas (PCCs) and paragangliomas. In this study, we explore new molecular …

Pheochromocytomas, intra-adrenal paraganglioma, and extra-adrenal sympathetic and
parasympathetic paragangliomas are neuroendocrine tumors derived from adrenal …

Serine/threonine-protein kinase B-Raf (BRAF; RAF= rapidly accelerated fibrosarcoma) plays
an important role in the mitogen-activated protein kinase (MAPK) signaling cascade …

Simple Summary Pancreatic neuroendocrine tumors (pNETs) are rare, indolent cancers
whose causation is only partly understood. An increasing number of studies have uncovered …

The RAS/mitogen-activated protein kinase (MAPK) signaling cascade is commonly
dysregulated in human malignancies by processes driven by RAS or RAF oncogenes …

Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer with a rising incidence (1500
US cases per year) that now exceeds that of cutaneous T-cell lymphoma and a mortality …

Leucine-rich repeat kinase-2 (LRRK2) mutations are the most important cause of familial
Parkinson's disease, and non-selective inhibitors are protective in rodent disease models …

Carcinoid tumors are neuroendocrine malignancies that frequently metastasize and secrete
hormones that cause debilitating symptoms in patients. In this study we report the effects of …

Purpose: Selective RAF-targeted therapy is effective in some patients with BRAFV600E-
mutated glioma, though emergent and adaptive resistance occurs through ill-defined …