Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies

J **e, Y Wang, W Choi, P Jangili, Y Ge, Y Xu… - Chemical Society …, 2021 - pubs.rsc.org
Photodynamic therapy (PDT) has been extensively investigated for decades for tumor
treatment because of its non-invasiveness, spatiotemporal selectivity, lower side-effects, and …

Nanoagent‐promoted mild‐temperature photothermal therapy for cancer treatment

G Gao, X Sun, G Liang - Advanced Functional Materials, 2021 - Wiley Online Library
Photothermal therapy (PTT), which utilizes near‐infrared light‐absorbing agents to ablate
tumor, has emerged as a highly promising anticancer strategy and received intensive …

Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents

HM Zhou, JG Zhang, X Zhang, Q Li - Signal transduction and targeted …, 2021 - nature.com
Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that
contribute to tumor progression and therapy resistance. However, the underlying processes …

Emerging trends in nanomaterials for antibacterial applications

S Yougbaré, C Mutalik, G Okoro, IH Lin… - International journal …, 2021 - Taylor & Francis
Around the globe, surges of bacterial diseases are causing serious health threats and
related concerns. Recently, the metal ion release and photodynamic and photothermal …

Cancer stem cell mimicry for immune evasion and therapeutic resistance

PE Saw, Q Liu, PP Wong, E Song - Cell Stem Cell, 2024 - cell.com
Cancer stem cells (CSCs) are heterogeneous, possess self-renewal attributes, and
orchestrate important crosstalk in tumors. We propose that the CSC state represents" …

Recent advances in calcium‐based anticancer nanomaterials exploiting calcium overload to trigger cell apoptosis

Y **ao, Z Li, A Bianco, B Ma - Advanced Functional Materials, 2023 - Wiley Online Library
Calcium ion is vital for the regulation of many cellular functions and serves as a second
messenger in the signal transduction pathways. Once the intracellular Ca2+ level exceeds …

Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy

L Galluzzi, JM Bravo-San Pedro, S Demaria… - Nature reviews Clinical …, 2017 - nature.com
Autophagy is fundamental to the maintenance of intracellular homeostasis in virtually all
human cells. Accordingly, defective autophagy predisposes healthy cells to undergoing …

Repurposing Drugs in Oncology (ReDO)—chloroquine and hydroxychloroquine as anti-cancer agents

C Verbaanderd, H Maes, MB Schaaf… - …, 2017 - pmc.ncbi.nlm.nih.gov
Chloroquine (CQ) and hydroxychloroquine (HCQ) are well-known 4-aminoquinoline
antimalarial agents. Scientific evidence also supports the use of CQ and HCQ in the …

Cell death pathways associated with photodynamic therapy: an update

D Kessel, NL Oleinick - Photochemistry and photobiology, 2018 - Wiley Online Library
Photodynamic therapy (PDT) has the potential to make a significant impact on cancer
treatment. PDT can sensitize malignant tissues to light, leading to a highly selective effect if …

3-Bromopyruvate-conjugated nanoplatform-induced pro-death autophagy for enhanced photodynamic therapy against hypoxic tumor

Y Deng, P Song, X Chen, Y Huang, L Hong, Q **… - ACS nano, 2020 - ACS Publications
Autophagy triggered by reactive oxygen species (ROS) in photodynamic therapy (PDT)
generally exhibits an anti-apoptotic effect to promote cell survival. Herein, an innovative …