Radiation therapy‐associated toxicity: Etiology, management, and prevention

K Wang, JE Tepper - CA: a cancer journal for clinicians, 2021 - Wiley Online Library
Radiation therapy (RT) is a curative treatment for many malignancies and provides effective
palliation in patients with tumor‐related symptoms. However, the biophysical effects of RT …

Evolution of systemic therapy for stages I–III non-metastatic non-small-cell lung cancer

JE Chaft, A Rimner, W Weder, CG Azzoli… - Nature reviews Clinical …, 2021 - nature.com
The treatment goal for patients with early-stage lung cancer is cure. Multidisciplinary
discussions of surgical resectability and medical operability determine the modality of …

Radiation-induced lung injury: assessment and management

AN Hanania, W Mainwaring, YT Ghebre, NA Hanania… - Chest, 2019 - Elsevier
Radiation-induced lung injury (RILI) encompasses any lung toxicity induced by radiation
therapy (RT) and manifests acutely as radiation pneumonitis and chronically as radiation …

[HTML][HTML] Cardiac toxicity of thoracic radiotherapy: existing evidence and future directions

K Banfill, M Giuliani, M Aznar, K Franks… - Journal of Thoracic …, 2021 - Elsevier
The impact of radiotherapy on the heart has become an area of interest in recent years.
Many different cardiac dose-volume constraints have been associated with cardiac toxicity …

Association of left anterior descending coronary artery radiation dose with major adverse cardiac events and mortality in patients with non–small cell lung cancer

KM Atkins, TL Chaunzwa, N Lamba… - JAMA …, 2021 - jamanetwork.com
Importance Radiotherapy accelerates coronary heart disease (CHD), but the dose to critical
cardiac substructures has not been systematically studied in lung cancer. Objective To …

Validation and modification of a prediction model for acute cardiac events in patients with breast cancer treated with radiotherapy based on three-dimensional dose …

VAB van den Bogaard, BDP Ta… - Journal of Clinical …, 2017 - ascopubs.org
Purpose A relationship between mean heart dose (MHD) and acute coronary event (ACE)
rate was reported in a study of patients with breast cancer (BC). The main objective of our …

Prevention and treatment of radiotherapy‐induced side effects

L Barazzuol, RP Coppes, P van Luijk - Molecular oncology, 2020 - Wiley Online Library
Radiotherapy remains a mainstay of cancer treatment, being used in roughly 50% of
patients. The precision with which the radiation dose can be delivered is rapidly improving …

Bayesian adaptive randomization trial of passive scattering proton therapy and intensity-modulated photon radiotherapy for locally advanced non–small-cell lung …

Z Liao, JJ Lee, R Komaki, DR Gomez… - Journal of Clinical …, 2018 - ascopubs.org
Purpose This randomized trial compared outcomes of passive scattering proton therapy
(PSPT) versus intensity-modulated (photon) radiotherapy (IMRT), both with concurrent …

Roadmap: proton therapy physics and biology

H Paganetti, C Beltran, S Both, L Dong… - Physics in Medicine …, 2021 - iopscience.iop.org
The treatment of cancer with proton radiation therapy was first suggested in 1946 followed
by the first treatments in the 1950s. As of 2020, almost 200 000 patients have been treated …

[HTML][HTML] 2nd ESMO Consensus Conference in Lung Cancer: locally advanced stage III non-small-cell lung cancer

WEE Eberhardt, D De Ruysscher, W Weder… - Annals of …, 2015 - Elsevier
To complement the existing treatment guidelines for all tumour types, ESMO organises
consensus conferences to focus on specific issues in each type of tumour. The 2nd ESMO …