Beyond their well-known functions in the acute phases of the immune response, neutrophils
play important roles in the various phases of tumor initiation and progression, through the …

Human neutrophils, the most abundant circulating leukocytes, are fundamental components
of the host response against different pathogens. Until a few years ago, neutrophils received …

Previous studies have shown that mouse dermis is composed of functionally distinct
fibroblast lineages. To explore the extent of fibroblast heterogeneity in human skin, we used …

Angiogenesis involves dynamic interactions between specialized endothelial tip and stalk
cells that are believed to be regulated in part by VEGF and Dll4-Notch signaling. However …

Mammalian organs comprise an extraordinary diversity of cell and tissue types.
Regenerative organs, such as the skin and gastrointestinal tract, use resident stem cells to …

Blood vessel formation is a fundamental process for the development of organism and tissue
regeneration. Of importance, angiogenesis occurring during postnatal development is …

Macrophage is one of the important players in immune response which perform many
different functions during tissue injury, repair, and regeneration. Studies using animal …

Although most tissue types are capable of some form of self-repair and regeneration, injuries
that are larger than a critical threshold or those occurring in the setting of certain diseases …

Therapeutic angiogenesis with mesenchymal stem cells (MSCs) is promising for the clinical
treatment of peripheral artery disease (PAD). However, the heterogeneous proangiogenic …

Dysfunctional endothelial cells contribute to the pathophysiology of many diseases,
including vascular disease, stroke, hypertension, atherosclerosis, organ failure, diabetes …