Bone remodeling replaces old and damaged bone with new bone through a sequence of
cellular events occurring on the same surface without any change in bone shape. It was …

Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

The bone matrix plays an indispensable role in the human body, and its unique
biomechanical and mechanobiological properties have received much attention. The bone …

Nowadays, orthodontic treatment has become increasingly popular. However, the biological
mechanisms of orthodontic tooth movement (OTM) have not been fully elucidated. We were …

Osteocytes, the most abundant and long-lived cells in bone, are the master regulators of
bone remodeling. In addition to their functions in endocrine regulation and calcium and …

In 1892, JL Wolff proposed that bone could respond to mechanical and biophysical stimuli
as a dynamic organ. This theory presents a unique opportunity for investigations on bone …

Osteoporosis is a pathological loss of bone mass due to an imbalance in bone remodeling
where osteoclast-mediated bone resorption exceeds osteoblast-mediated bone formation …

Disuse osteoporosis describes a state of bone loss due to local skeletal unloading or
systemic immobilization. This review will discuss advances in the field that have shed light …

Trabecular bone is a highly porous, heterogeneous, and anisotropic material which can be
found at the epiphyses of long bones and in the vertebral bodies. Studying the mechanical …

Few investigators think of bone as an endocrine gland, even after the discovery that
osteocytes produce circulating fibroblast growth factor 23 that targets the kidney and …