[HTML][HTML] Hallmarks of aging: An expanding universe
Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …
Hallmarks of cardiovascular ageing
Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …
ATP and cancer immunosurveillance
While intracellular adenosine triphosphate (ATP) occupies a key position in the bioenergetic
metabolism of all the cellular compartments that form the tumor microenvironment (TME) …
metabolism of all the cellular compartments that form the tumor microenvironment (TME) …
Bodywide ecological interventions on cancer
Historically, cancer research and therapy have focused on malignant cells and their tumor
microenvironment. However, the vascular, lymphatic and nervous systems establish long …
microenvironment. However, the vascular, lymphatic and nervous systems establish long …
Geroscience‐guided repurposing of FDA‐approved drugs to target aging: A proposed process and prioritization
AS Kulkarni, S Aleksic, DM Berger, F Sierra… - Aging …, 2022 - Wiley Online Library
Common chronic diseases represent the greatest driver of rising healthcare costs, as well as
declining function, independence, and quality of life. Geroscience‐guided approaches seek …
declining function, independence, and quality of life. Geroscience‐guided approaches seek …
Autophagy in health and disease: From molecular mechanisms to therapeutic target
Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …
Targeting immunogenic cell stress and death for cancer therapy
Immunogenic cell death (ICD), which results from insufficient cellular adaptation to specific
stressors, occupies a central position in the development of novel anticancer treatments …
stressors, occupies a central position in the development of novel anticancer treatments …
[HTML][HTML] IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms
Q Wu, AL Tian, B Li, M Leduc, S Forveille… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Pharmacological autophagy enhancement constitutes a preclinically validated
strategy for preventing or treating most major age-associated diseases. Driven by this …
strategy for preventing or treating most major age-associated diseases. Driven by this …
A collective analysis of lifespan-extending compounds in diverse model organisms, and of species whose lifespan can be extended the most by the application of …
Research on aging and lifespan-extending compounds has been carried out using diverse
model organisms, including yeast, worms, flies and mice. Many studies reported the …
model organisms, including yeast, worms, flies and mice. Many studies reported the …
Immunogenic cell stress and death in the treatment of cancer
The successful treatment of oncological malignancies which results in long-term disease
control or the complete eradication of cancerous cells necessitates the onset of adaptive …
control or the complete eradication of cancerous cells necessitates the onset of adaptive …