Globally, about 400 million people reside at terrestrial altitudes above 1500 m, and more
than 100 million lowlanders visit mountainous areas above 2500 m annually. The …

During exercise, fatigue is defined as a reversible reduction in force-or power-generating
capacity and can be elicited by “central” and/or “peripheral” mechanisms. During skeletal …

Altitude exposure is associated with major changes in cardiovascular function. The initial
cardiovascular response to altitude is characterized by an increase in cardiac output with …

Changing arterial oxygen content (C) has a highly sensitive influence on the rate of
peripheral locomotor muscle fatigue development. We examined the effects of C on exercise …

It has been hypothesized that one reason for decreased ̇ VO _ 2\max in hypoxia could be
the lower maximal exercise intensity achieved in incremental, time or distance trial tests. We …

The key elements in acclimatization aim at securing the oxygen supply to tissues and organs
of the body with an optimal oxygen tension of the arterial blood. In acute exposure …

To determine if fatigue at maximal aerobic power output was associated with a critical
decrease in cerebral oxygenation, 13 male cyclists performed incremental maximal exercise …

We examined the effects of hypoxia severity on peripheral versus central determinants of
exercise performance. Eight cyclists performed constant‐load exercise to exhaustion at …

Classically the limit to endurance of exercise is explained in terms of metabolic capacity.
Cardio-respiratory capacity and muscle fatigue are thought to set the limit and the majority of …

A central debate in the exercise sciences is the cause of the fatigue that develops especially
during high intensity exercise of short duration. The most popular theory holds that this form …