Diabetes mellitus increases the risk of develo** cardiovascular diseases such as coronary
artery disease and heart failure. Studies have shown that the heart failure risk is increased in …

Myocardial stretch elicits a rapid increase in developed force, which is mainly caused by an
increase in myofilament calcium sensitivity (Frank-Starling mechanism). Over the ensuing 10 …

The positive findings of the EMPA-REG OUTCOME trial (Randomized, Placebo-Controlled
Cardiovascular Outcome Trial of Empagliflozin) on heart failure (HF) outcome in patients …

In addition to their central role in ATP synthesis, mitochondria play a critical role in cell
death. Oxidative stress accompanied by calcium overload, ATP depletion, and elevated …

The incidence of cardiovascular complications associated with hyperglycemia is a growing
global health problem. This review discusses the link between hyperglycemia and …

Studies on the role of mitochondrial fission/fusion (MFF) proteins in the heart have been
initiated recently due to their biological significance in cell metabolism. We hypothesized …

Background The use of percutaneous coronary intervention (PCI) in patients with ST‐
segment elevation myocardial infarction (STEMI) is associated with a mortality rate of 5 …

Mitochondria represent major sources of basal reactive oxygen species (ROS) production of
the cardiomyocyte. The role of ROS as signaling molecules that mediate different …

In this review, we describe key signaling pathways regulating potassium channels present in
the inner mitochondrial membrane. The signaling cascades covered here include …

Significance: Cardiovascular complications in diabetes are particularly serious and
represent the primary cause of morbidity and mortality in diabetic patients. Despite early …